ArticleO&G open2024
Association of Resolved Low-Lying Placentation With Risk of Postpartum Hemorrhage.
Abstract read
In one paragraph
Article in O&G open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Low-lying placenta is associated with increased risk of hemorrhage and severe maternal morbidity: A nationwide analysis.Pregnancy (Hoboken, N.J.) · 2026Article
- Marginal Sinus and Bleeding in Women with a Low-Positioned Placenta: A Narrative Synthesis Systematic Review.Women's health reports (New Rochelle, N.Y.) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Sara OrnaghiUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Elisabetta ColciagoUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Laura MonteliscianiUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Francesca ArientiUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Federica FernicolaUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Alessandra AbbamondiUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Sofia GianiUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Simona FumagalliUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Laura AntoliniUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Isadora Vaglio TessitoreUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Giulia ZangheriUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Elena GattiUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Michele VignaliUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Clelia CallegariUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Andrea SalaUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Cristina PlevaniUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Maddalena SmidUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Mirko PozzoniUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Maria CastoldiUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Sara BenedettiUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Mario G MeroniUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Camilla BulfoniUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Anna CatalanoUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Sara ConsonniUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Anna FicheraUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Elisa FabbriUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Patrizia VerganiUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Anna LocatelliUnit of Obstetrics, Foundation IRCCS San Gerardo dei Tintori, the University of Milan-Bicocca, School of Medicine and Surgery, and the 4 Center of Bioinformatics, Biostatistics, and Bioimaging, School of Medicine and Surgery, University of Milan-Bicocca, Monza, the Unit of Obstetrics and Gynecology, Vittorio Emanuele III Hospital, ASST Brianza, Carate Brianza, the Unit of Obstetrics and Gynecology, Macedonio Melloni Hospital, ASST Fatebenefratelli Sacco, the Unit of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, the Unit of Obstetrics and Gynecology, ASST Grande Ospedale Metropolitano Niguarda, and the Unit of Obstetrics and Gynecology, Vittore Buzzi Hospital, ASST Fatebenefratelli Sacco, University of Milan, School of Medicine and Surgery, Milan, the Unit of Obstetrics and Gynecology, Alessandro Manzoni Hospital, ASST Lecco, Lecco, the Unit of Obstetrics and Gynecology, Poliambulanza Foundation Hospitals, and the Unit of Obstetrics and Gynecology, Spedali Civili Hospital, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate whether individuals who have a placenta previa or low-lying placenta that resolves before delivery are at increased risk of postpartum hemorrhage and postpartum hemorrhage-related morbidity.
methodsThis was a prospective, multicenter, 1:3 matched cohort study of pregnant individuals with singleton gestations diagnosed with low placentation by transvaginal scan at 19 to 23 weeks of gestation between January 2021 and December 2023 at nine academic maternity centers (exposed participants). Unexposed participants were those with a normally located placenta, matched in a 1:3 ratio according to parity. Resolution of low placentation was diagnosed when placenta was at 20 mm or more from the internal os. Individuals with fetal anomalies, hematologic disorders, therapeutic anticoagulation, placenta accreta spectrum disorder, vasa previa, persistent low placentation at birth, and delivery at a nonenrolling center were excluded. Primary outcome was postpartum hemorrhage of 1,000 mL or more. Secondary outcomes included postpartum hemorrhage of 1,500 mL or more, use of second-line uterotonic drugs, blood transfusions, additional procedures to control bleeding, intensive care unit admission, and hospital stay for more than 7 days. Multivariable logistic regression adjusted for confounders was used to estimate independent associations with outcomes.
resultsThe study population included 182 exposed and 589 unexposed participants. Individuals with resolved low placentation had higher rates of smoking (
conclusionIndividuals with resolved low placentation are at increased risk of postpartum hemorrhage and related complications compared with those who always had a normally located placenta.
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