ArticleResearch square2025
Precise limb-speed afference reveals rhythmogenic drive modality and declines with age.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Human locomotion requires precise coordination of bilateral limb movements that degrades with age increasing frailty and loss of independence. Here we tested whether the nervous system senses small differences in limb speed and whether this signal is independent of loading and changes across the lifespan. Using a two-alternative forced-choice task on a split-belt treadmill, healthy young adults detected inter-limb speed differences as small as 1.3% (mean 1.3%, standard deviation 0.6%). Manipulating whole-body load by ±10% did not alter thresholds, consistent with computation of whole-limb speed rather than raw somatosensory drive. Across ages 6-80 years, discrimination followed a U-shaped trajectory: thresholds were higher in children, lowest in young adults, and increased in middle-aged and older adults. Here, we show that limb-speed afference is measured with high acuity in humans and declines with age, supporting its role as a control variable for rhythmogenic circuits and highlighting a potential target for assessment and rehabilitation in age-related mobility decline.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.