ArticleResearch square2025
Early Symptom Warnings and Long-Term Health Conditions in Childhood Cancer Survivors: Insights from the Childhood Cancer Survivor Study and St. Jude Lifetime Cohort Study.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Symptom patterns in adult survivors of childhood cancer may signal risk for health deterioration and offer a foundation for risk stratification. 735 survivors completed sequential symptom surveys (T1, T2, T3) and clinical assessment for chronic health conditions (CHCs). Survivors were classified into four clusters: 1) low physical and emotional symptoms, 2) moderate physical and low emotional symptoms, 3) moderate physical and emotional symptoms, and 4) high physical and emotional symptoms. Survivors in cluster 4 vs. cluster 1 had an elevated risk of progressive total CHC burden and vascular, respiratory, neurologic, and musculoskeletal conditions (relative risk [RR] range: 1.24-2.53). Increased/persistently high symptom burden between T1-T2 increased risk for progressive total CHC burden, respiratory, and neurologic conditions (RR range: 1.30-2.23). Increased/persistently high T2-T3 symptom burden showed similar associations (all p's < 0.05). This proof-of-concept study provides an empirical basis for developing and validating symptom-based prediction models and warning systems to support proactive survivorship care.
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