Evidence map›Paper›PMID 41001540›Full record

ArticleResearch square2025

Alzheimer's Disease-Like Brain Pattern Biomarker: Capturing Risks and Predicting Disease Onset.

Peter Kochunov, Si Gao, Lauren Salminen, Neda Jahanshad, Talia Nir, Paul Thompson, Xiaoming Du, Bhim Adhikari, Alice Kochunov, Ryan Cassidy and 9 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Peter KochunovThe University of Texas Health Science Center at Houston.
Si GaoThe University of Texas Health Science Center at Houston.ORCID 0000-0002-4473-1142
Lauren SalminenUniversity of Southern California.
Neda JahanshadUniversity of Southern California.
Talia NirUniversity of Southern California Keck School of Medicine.ORCID 0000-0002-7106-7443
Paul ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, USA.
Xiaoming DuUniversity of Maryland Baltimore.
Bhim AdhikariMaryland Psychiatric Research Center.
Alice KochunovMaryland Psychiatric Research Center.
Ryan CassidyThe University of Texas Health Science Center at Houston.
Yizhou MaThe University of Texas Health Science Center at Houston.
Joshua ChiappelliUniversity of Maryland Baltimore.ORCID 0000-0001-6121-7439
Seth AmentUniversity of Maryland School of Medicine.ORCID 0000-0001-6443-7509
Yezhi PanUniversity of Maryland Baltimore.
Shuo ChenUniversity of Maryland School of Medicine.
Alan ShuldinerUniversity of Maryland School of Medicine.
Braxton MitchellUniversity of Maryland School of Medicine.ORCID 0000-0003-4920-4744
Jair SoaresMcGovern Medical School.ORCID 0000-0002-5466-5628
Elliot Hong

Funding

SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Amish Connectome Project on Mental IllnessU01MH108148 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2015 to 2018
$4.3M
Towards Multisystem-Brain Successful Aging in Schizophrenia SpectrumR01MH116948 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HONG, L ELLIOT ELLIOT · 2018 to 2022
$3.7M
Lifespan Vascular Biology on White MatterRF1NS114628 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2020 to 2020
$3.1M
Worldwide Mapping of Air Pollution Exposure Patterns on Aging Brain HealthR01ES033961 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Lauren E. Salminen · 2022 to 2026
$2.7M
The Vascular Axis in Schizophrenia Brain-Body AgingR01MH133812 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI L Elliot Elliot Hong · 2024 to 2026
$2.2M
A global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA ConsortiumR01MH117601 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA, SCHMAAL, LIANNE · 2018 to 2021
$1.5M
Redefine Trans-Neuropsychiatric Disorder Brain Patterns through Big-Data and Machine LearningRF1MH123163 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V., THOMPSON, PAUL M · 2021 to 2021
$1.2M
The Role of Stress-Immune-Connectome Disruption in Mechanisms of Chinese Early Schizophrenia SpectrumR01MH112180 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT · 2017 to 2021
$1.0M
Lifespan Vascular Biology on White MatterR01NS114628 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT, KOCHUNOV, PETER V. · 2024 to 2024
$770k
Hybrid GPU/CPU Computing Resource to Support Connectomic and GenomicsS10OD023696 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI KOCHUNOV, PETER V. · 2018 to 2018
$593k
NIBIB NIH HHS R01 EB015611NIEHS NIH HHS R01 ES033961NIH HHS S10 OD023696NIMH NIH HHS R01 MH112180NIMH NIH HHS R01 MH116948NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH133812NIMH NIH HHS RF1 MH123163NIMH NIH HHS U01 MH108148NINDS NIH HHS R01 NS114628NINDS NIH HHS RF1 NS114628
6 · The paper itself

Abstract

Preventing Alzheimer's disease (

Indexed as

Alzheimer’s diseaseamyloidBig datacerebrovascular diseaseneuroimagingRVI

Identifiers

PMID41001540
PMCPMC12458576

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.