ArticleResearch square2025
Identifying caregiver-reported modifiable barriers to pediatric oncology clinical trial enrollment and participation.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Purpose: Clinical trial (ClTr) participation is critical to high-quality pediatric oncology care, but significant sociodemographic disparities in trial enrollment exist. Identifying modifiable barriers to participation such as household material hardship (HMH) and limited health literacy (HL), is essential to improving ClTr access. We compared differences in caregiver-reported barriers to pediatric oncology ClTr participation across socioeconomic status (SES) and racial and ethnic groups through a nationwide anonymous online survey of caregivers of children with cancer. We also explored associations between caregiver HL, HMH, and barriers to trial participation. Methods: English- and/or Spanish-speaking caregivers of children diagnosed with cancer in the last 5 years completed the Research Participation Survey - Caregiver (RPS-C) to assess barriers to ClTr participation, the validated Health Literacy Survey-12 (HLS Results: Of 59 participants, 64% were socioeconomically under-resourced, 52.5% identified as racially or ethnically underrepresented, and 62% reported their child had not participated in a ClTr. Under-resourced caregivers reported higher RPS-C barrier scores than adequately resourced caregivers ( Conclusions: Under-resourced SES, HMH, and lower HL were associated with increased barriers to ClTr participation. Caregivers reported modifiable barriers that could be targets for intervention to improve ClTr participation and reduce disparities in childhood cancer outcomes.
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