More severe history of childhood adversity is linked to greater surface area of induced secondary hyperalgesia.

Gillian J Bedwell, Luyanduthando Mqadi, Mark R Hutchinson, Romy Parker, Victoria J Madden

Abstract readPreprint

In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Gillian J BedwellAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4522-5679

Luyanduthando MqadiAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-0542-2221

Mark R HutchinsonSchool of Biomedicine, University of Adelaide, South Australia, Australia.ORCID 0000-0003-2154-5950

Romy ParkerAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4823-2487

Victoria J MaddenAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-5357-4062

Funding

Psychosocial distress, inflammatory reactivity and central sensitization in the pathway to HIV-related pain: characterizing the associations and developing a pragmatic, coping-focused intervention.K43TW011442 · FIC · UNIVERSITY OF CAPE TOWN · PI MADDEN, VICTORIA JOY · 2019 to 2023

$674k

FIC NIH HHS K43 TW011442

6 · The paper itself

Abstract

Childhood adversity is linked to persistent pain in adulthood. Nociceptive upregulation may play a role in this relationship. We investigated whether childhood adversity is associated with measures of nociceptive processing, and whether these associations differ by sex. In this experimental observational study, we enrolled pain-free adults with varying severity of childhood adversity, scored on the Childhood Trauma Questionnaire-Short Form. Measures of nociceptive processing included the surface area and magnitude of induced secondary hyperalgesia, temporal summation, and conditioned pain modulation. We used linear regression to investigate whether childhood adversity was associated with increased surface area or magnitude of secondary hyperalgesia, increased temporal summation, or reduced conditioned pain modulation, and whether these relationships differed by sex. Ninety-five participants (61 female; median age 23 [IQR: 9] years) completed the study. Childhood adversity was positively associated with the surface area of secondary hyperalgesia (β=0.32 [95%CI: 0.01; 0.62],

Indexed as

Childhood adversityConditioned pain modulationPainSecondary hyperalgesiaSex

Identifiers

PMID41001513

DOI10.1101/2025.09.16.25335844

PMCPMC12458492

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.