Evidence map›Paper›PMID 41001418›Full record

ArticleFrontiers in cellular and infection microbiology2025

Alternative splicing is a driving force that tunes metabolic adaptations to virulence traits in the dermatophyte

Marcos E Ramos Lopes, João Neves-da-Rocha, Pablo R Sanches, Vanderci M Oliveira, Antonio Rossi, Nilce M Martinez-Rossi

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marcos E Ramos LopesDepartment of Genetics, Ribeirão Preto Medical School, University of Sao Paulo, USP, Ribeirão Preto, SP, Brazil.
João Neves-da-RochaDepartment of Genetics, Ribeirão Preto Medical School, University of Sao Paulo, USP, Ribeirão Preto, SP, Brazil.
Pablo R SanchesDepartment of Genetics, Ribeirão Preto Medical School, University of Sao Paulo, USP, Ribeirão Preto, SP, Brazil.
Vanderci M OliveiraDepartment of Genetics, Ribeirão Preto Medical School, University of Sao Paulo, USP, Ribeirão Preto, SP, Brazil.
Antonio RossiDepartment of Genetics, Ribeirão Preto Medical School, University of Sao Paulo, USP, Ribeirão Preto, SP, Brazil.
Nilce M Martinez-RossiDepartment of Genetics, Ribeirão Preto Medical School, University of Sao Paulo, USP, Ribeirão Preto, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Alternative splicing (AS), a common process in pathogenic fungal species, is not fully understood. We hypothesized that AS is a critical regulatory mechanism that enables species to undergo continuous adaptations during interactions with challenging host environments. Methods: We utilized the model species Results and discussion: Overall, the results showed that AS is recruited to regulate approximately 12.6% of the Conclusions: Our data indicate that mRNA isoforms originating from AS contribute to the adaptation of

Indexed as

Adaptation, PhysiologicalAlternative SplicingArthrodermataceaeTrichophytonFungal ProteinsGene Expression ProfilingGene Expression Regulation, FungalHost-Pathogen InteractionsHumansKeratinocytesNailsTineaTranscription FactorsTranscriptomeVirulenceFungal ProteinsTranscription Factorsalternative splicingAp1Con7fungal pathogenintron retentionmetabolismPacCtranscription factor

Identifiers

PMID41001418
PMCPMC12457390

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.