ReviewFrontiers in medicine2025
Mediastinal infections: diagnostic and therapeutic advances from traditional surgery to novel minimally invasive techniques.
Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mediastinitis after cardiac surgery, from microbes to management: a systematic review.Mediastinum (Hong Kong, China) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mediastinal infections present significant diagnostic and therapeutic challenges, contributing to highly variable mortality. Diagnostic dilemmas arise from complex anatomy and radiographic similarities to malignancies. Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) and cultures are constrained by small samples, architectural distortion, low sensitivity, and slow results in special circumstances. Therapeutic obstacles include antibiotic resistance, poor antimicrobial penetration due to altered vascularity, and high surgical morbidity. Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (EBUS-TMC) provides larger histologically preserved specimens; metagenomic next-generation sequencing (mNGS) achieves rapid sensitive pathogen detection; advanced imaging (Dual Energy Computed Tomography, DECT; Positron Emission Tomography/Computed Tomography, PET/CT) enhances lesion differentiation and intervention planning; while minimally invasive drainage, nanocarrier-based targeted antimicrobial delivery, and reconstructive techniques collectively reduce complications and improve therapeutic efficacy. Multidisciplinary integration of these innovations is advancing precision medicine approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.