Evidence map›Paper›PMID 41001300›Full record

ArticleCureus2025

An Autopsy Case of Neurofibromatosis Type 1 Mutation Detected in a Duodenal Lesion of Malignant Melanoma: A Case Report.

Mai Seki, Emi Saitou, Shintaro Saito, Takeshi Araki, Yoichiro Shinohara, Kazuyoshi Fujihira, Tetsunari Oyama, Hideaki Yokoo

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mai SekiDiagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, JPN.
Emi SaitouDiagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, JPN.
Shintaro SaitoDermatology, Gunma University Graduate School of Medicine, Maebashi, JPN.
Takeshi ArakiDermatology, Gunma University Graduate School of Medicine, Maebashi, JPN.
Yoichiro ShinoharaOphthalmology, Gunma University Graduate School of Medicine, Maebashi, JPN.
Kazuyoshi FujihiraPsychiatry and Neuroscience, Gunma University Graduate School of Medicine, Maebashi, JPN.
Tetsunari OyamaDiagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, JPN.
Hideaki YokooHuman Pathology, Gunma University Graduate School of Medicine, Maebashi, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report an autopsy case of duodenal malignant melanoma (MM) in a patient with neurofibromatosis type 1 (NF1). The patient had an anamnesis of choroidal MM, and the duodenal lesion was initially suspected to be a metastasis from the choroidal tumor. At autopsy, the duodenum was occupied by a tumor composed of large atypical cells on histopathological examination. Immunohistochemically, the nuclei of large atypical cells were positive for Melan A, HMB-45, and SOX-10, confirming the diagnosis of MM. Next-generation sequencing (NGS) of the duodenal tumor sample identified an NF1 mutation, with no other gene mutations clearly associated with malignant transformation.

Indexed as

duodenummalignant melanomanf1sox-10von recklinghausen disease

Identifiers

PMID41001300
PMCPMC12458915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.