Evidence map›Paper›PMID 41001218›Full record

ArticleO&G open2024

Adjuvant Chemotherapy for Stage I Ovarian Clear Cell Carcinoma.

Naoki Horikawa, Yoshihide Inayama, Miki Otsuki, Kota Yamauchi, Yukako Mizuno, Saya Kiyoshige, Yukiko Taga, Kazuki Yamano, Maki Umemiya, Motonori Matsubara and 6 more

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Article in O&G open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Naoki HorikawaDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Yoshihide InayamaDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Miki OtsukiDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Kota YamauchiDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Yukako MizunoDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Saya KiyoshigeDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Yukiko TagaDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Kazuki YamanoDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Maki UmemiyaDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Motonori MatsubaraDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Yukio YamanishiDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Takahito AshiharaDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Ikuko EmotoDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Masaki MandaiDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Kenzo KosakaDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.
Ken YamaguchiDepartments of Obstetrics and Gynecology, Kurashiki Central Hospital, Okayama, Kyoto University Hospital and Kyoto Medical Center, Kyoto, Kitano Hospital and Osaka Red Cross Hospital, Osaka, Nagahama Red Cross Hospital, Shiga, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Toyooka Hospital, Hyogo, and Shizuoka General Hospital, Shizuoka, Japanese Red Cross Wakayama Medical Center, Wakayama, and the Department of Gynecology, Shiga General Hospital, Shiga, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the association between postoperative chemotherapy and the prognosis of patients with stage I ovarian clear cell carcinoma.

methodsThis was a retrospective cohort study of patients with stage I ovarian clear cell carcinoma who underwent surgery, including hysterectomy and bilateral salpingo-oophorectomy, between 2005 and 2019 at 11 affiliated institutions. Patients with preoperative lymph node enlargement, and those who underwent fertility-sparing surgery were excluded. The primary outcome was disease-free survival and overall survival, and was investigated as a secondary outcome. We used propensity score overlap weighting to adjust for confounding factors and estimated the adjusted hazard ratios (HRs) and 95% CIs for the disease-free and overall survival of patients in the control group that did not receive chemotherapy and in the platinum-based multiagent chemotherapy group during the follow-up period.

resultsIn total, 283 patients (64 in the control group and 219 in the chemotherapy group) were included. Five-year disease-free survival was 0.77 (95% CI, 0.66-0.89) in the control group and 0.86 (95% CI, 0.81-0.91) in the chemotherapy group. The unadjusted HR was 0.69 (95% CI, 0.36-1.32;

conclusionPostoperative platinum-based multiagent chemotherapy was associated with improved disease-free survival. These findings provide crucial information for shared decision-making regarding whether to undergo adjuvant chemotherapy.

Identifiers

PMID41001218
PMCPMC12456521

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