ArticleFrontiers in neurology2025
The effect of pituitary neuroendocrine tumors on the volumes of intracranial structures.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A prospective observational within-person MRI morphometric study comparing ictal and interictal brain volumes in status migrainosus.Neuroimage. Reports · 2026Article
- Latent Class Analysis of Negative Emotion Subtypes and Their Association With Quality of Life in Patients With Pituitary Neuroendocrine Tumors.Brain and behavior · 2026Article
- Bilateral approach selection in neuroendoscopic surgery for pituitary adenomas and health economic evaluation.Frontiers in surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Pituitary Neuroendocrine Tumors (PitNETs) can cause symptoms via mass effect or hormonal imbalances. This study investigated whether PitNETs induce volumetric changes in intracranial structures and assessed the diagnostic potential of these changes. Materials and methods: A retrospective analysis was conducted on 90 PitNET patients and 86 healthy controls. MRI data, acquired on a 1.5 Tesla scanner, were processed using the automated Vol2Brain system to calculate relative brain volumes. Results: PitNET patients exhibited significantly lower relative volumes across numerous brain structures compared to controls. This included reduced intracranial, cerebral, and cortical gray matter (GM), as well as temporal lobe, vermis, limbic lobe, hippocampus, and inferior lateral ventricle (ILV) volumes. Gyrus-level analysis also revealed significantly smaller volumes in key regions like the posterior orbital gyrus, supplementary motor cortex, and entorhinal area in PitNET patients. ROC analysis demonstrated good to very good diagnostic performance for ILV volume (AUC = 0.863; Conclusion: Our findings indicate significant volumetric reductions in various brain regions in PitNET patients, potentially explaining observed emotional and cognitive symptoms. The diagnostic utility of ILV and subcortical GM volumes is promising, suggesting their value as diagnostic adjuncts. These objective volumetric assessments may assist in surgical planning and patient stratification, though further prospective research is warranted to establish direct links with clinical outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.