ArticleClinical case reports2025
Regenerative Endodontic Treatment in an Immature Permanent Tooth With Necrotic Pulp and Periradicular Lesion.
Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Antibiotic approaches to endodontic regeneration.Biomaterial investigations in dentistry · 2026Review
- Longitudinal periapical radiographic evaluation of apexification, vital pulpotomy, and revascularization in immature permanent teeth: a retrospective comparative study.Frontiers in bioengineering and biotechnology · 2026Article
- Regenerative Endodontic Treatment in an Immature Permanent Tooth With Necrotic Pulp and Periradicular Lesion.Clinical case reports · 2025Article
- Nonsurgical Management of a Tooth With Intracanal Fiber Post and Periapical Lesion Using Guided Endodontic Technique.Clinical case reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Managing necrotic immature permanent teeth with an open apex presents a treatment challenge. Regenerative endodontic procedures have emerged as biologically based approaches for these cases, suggesting an alternative to conventional apexification. This report describes successful revascularization of an immature mandibular second premolar with a chronic apical abscess. Following canal disinfection with NaOCl irrigation and applying a calcium hydroxide as an intracanal medicament, a scaffold was created by inducing a blood clot within the canal. During follow-up sessions, the tooth remained asymptomatic and clinically functional. Radiographic evidence demonstrated ongoing apical root development with increases in both root length and dentinal-wall thickness, along with signs of apical closure. The treatment outcome supports the premise that conservative pulp revascularization can promote complete root maturation by preserving the vitality of dental pulp stem cells and providing a conducive environment for pulp regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.