ArticleFrontiers in nutrition2025
Dose-dependent interaction of dietary vitamin B2 and E in relation to cognitive performance: a cross-sectional study of older adults.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: While individual associations of dietary vitamins with cognitive function have been widely studied, the combined role of vitamin B2 and E remains poorly understood. This study investigates their interactive effects on cognitive performance in older adults. Methods: In this cross-sectional analysis of 2,497 participants (age ≥60 years) from NHANES 2011-2014, cognitive function was assessed using the Digit Symbol Substitution Test (DSST), with low performance defined as DSST scores <33 (lowest quartile). Dietary intake of vitamins B2 and E was derived from two 24-h recalls. Multivariable logistic regression models adjusted for sociodemographic, lifestyle, and clinical covariates examined independent and joint associations, with interaction effects quantified using product terms. Results: Following comprehensive adjustment, elevated dietary intake of vitamin B2 [odds ratio (OR) = 0.74, 95% confidence interval (CI): 0.58-0.95] and vitamin E (OR = 0.73, 95% CI: 0.56-0.94) was independently associated with diminished odds of low cognitive function. A significant multiplicative interaction was observed (OR = 1.15, 95% CI: 1.05-1.26; Conclusion: Our findings highlight a dose-dependent interplay between vitamins B2 and E in modulating cognitive performance, advocating for dietary guidelines to prioritize nutrient interaction patterns in aging populations.
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