Evidence map›Paper›PMID 41001030›Full record

ArticleFrontiers in oncology2025

Successful rescue of PD-1 inhibitor-induced TEN by vincristine combination therapy: a case report and literature review.

Hui-Yi Huang, Jia-Qi Liu, Yun-Yun Zeng, Zhi-Hao Huang, Shan Su

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hui-Yi HuangDepartment of Oncology, Guangzhou Chest Hospital, Guangzhou, China.
Jia-Qi LiuDepartment of Oncology, Guangzhou Chest Hospital, Guangzhou, China.
Yun-Yun ZengDepartment of Oncology, Guangzhou Chest Hospital, Guangzhou, China.
Zhi-Hao HuangDepartment of Oncology, Guangzhou Chest Hospital, Guangzhou, China.
Shan SuDepartment of Oncology, Guangzhou Chest Hospital, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the growing use of immune checkpoint inhibitors (ICIs) in the management of various solid malignancies, immune-related adverse events (irAEs) are increasingly recognized. Toxic epidermal necrolysis (TEN), though rare, represents a severe and potentially fatal cutaneous irAE with a high mortality rate. Owing to its low incidence and limited clinical data, a standardized treatment approach for ICI-induced TEN has not been established. We present a patient who developed TEN following the administration of a programmed cell death-1 inhibitor. The patient was successfully managed with a combination of vincristine, intravenous immunoglobulin, and glucocorticoids at the Department of Oncology, Guangzhou Chest Hospital.

Indexed as

immune check point inhibitor (ICI)immune-related adverse events (IRAE)PD-1 inhibitortoxic epidermal necrolysis (TEN)vincristine (VCR)

Identifiers

PMID41001030
PMCPMC12457164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.