Evidence map›Paper›PMID 41001027›Full record

ArticleFrontiers in oncology2025

Hepatic involvement as an initial manifestation of multiple myeloma: a case report with atypical imaging features.

Zongsheng Pu, Lujiang Zhan, Yimi Zha, Yilin Li, Shilin Qiu, Yinfu He, Yanhong Yang, Zaihui Feng, Xingxing Zhu

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Metabolically Silent Diffuse Hepatic Involvement in Multiple Myeloma: AnMolecular imaging and radionuclide therapy · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zongsheng PuDepartment of Radiology, The Third People's Hospital of Honghe Hani and Yi Autonomous Prefecture, Gejiu, Yunnan, China.
Lujiang ZhanDepartment of Radiology, The Third People's Hospital of Honghe Hani and Yi Autonomous Prefecture, Gejiu, Yunnan, China.
Yimi ZhaDepartment of Radiology, The Third People's Hospital of Honghe Hani and Yi Autonomous Prefecture, Gejiu, Yunnan, China.
Yilin LiDepartment of Pathology, The Third People's Hospital of Honghe Hani and Yi Autonomous Prefecture, Gejiu, Yunnan, China.
Shilin QiuDepartment of Radiology, The Third People's Hospital of Honghe Hani and Yi Autonomous Prefecture, Gejiu, Yunnan, China.
Yinfu HeDepartment of Radiology, The Third People's Hospital of Honghe Hani and Yi Autonomous Prefecture, Gejiu, Yunnan, China.
Yanhong YangDepartment of Radiology, The Third People's Hospital of Honghe Hani and Yi Autonomous Prefecture, Gejiu, Yunnan, China.
Zaihui FengDepartment of Radiology, The Third People's Hospital of Honghe Hani and Yi Autonomous Prefecture, Gejiu, Yunnan, China.
Xingxing ZhuDepartment of Radiology, The Third People's Hospital of Honghe Hani and Yi Autonomous Prefecture, Gejiu, Yunnan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic involvement as the initial manifestation of multiple myeloma (MM) is exceedingly rare and presents significant diagnostic challenges due to its heterogeneous imaging features, which often mimic metastatic liver tumors. We report a case of a 62-year-old man presenting with right upper quadrant discomfort. Imaging revealed a hypoechoic lesion in segment II of the liver on ultrasound, a low-density area with mild enhancement on contrast-enhanced CT, and atypical MRI features including hyperintensity on T1- and T2-weighted images, mild diffusion restriction on diffusion-weighted imaging (DWI), and minimal enhancement post-Gd-DTPA administration. Histopathology demonstrated diffuse infiltration of atypical plasma cells consistent with plasmacytoma, supported by immunohistochemical positivity for CD138, CD38, MUM1, and CD56, and an elevated serum β

Indexed as

differential diagnosisextramedullary myelomahepatic involvementimagingmultiple myeloma

Identifiers

PMID41001027
PMCPMC12457159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.