Evidence map›Paper›PMID 41000981›Full record

ArticlebioRxiv : the preprint server for biology2025

Impact Induces Phagocytic Defect in Reactive Microglia.

Ruilin Yu, Edmond A Rogers, Palak Manchanda, Connor H Beveridge, Caitlin E Randolph, Timothy B Beauclair, Krupal P Jethava, Riyi Shi, Gaurav Chopra

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruilin YuDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-2060-2565
Edmond A RogersWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-0617-0719
Palak ManchandaDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0001-6194-8282
Connor H BeveridgeDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Caitlin E RandolphDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA.ORCID 0009-0002-5010-2075
Timothy B BeauclairWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-9257-3329
Krupal P JethavaDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-4440-3333
Riyi ShiWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Gaurav ChopraDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0003-0942-7898

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Chemical instruments-aware distributed blockchain based open AI platform to accelerate drug discoveryU18TR004146 · NCATS · PURDUE UNIVERSITY · PI CHOPRA, GAURAV, JAYACHANDRAN, GUHA · 2022 to 2023
$1.1M
NCATS NIH HHS U18 TR004146NCATS NIH HHS UL1 TR002529
6 · The paper itself

Abstract

We have developed traumatic brain injury (TBI)-on-a-chip in vitro models using primary microglia and neuronal networks and recorded the molecular and cellular changes following impact to represent impact injury. Using a pH-responsive amyloid β (Aβ

Identifiers

PMID41000981
PMCPMC12458479

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.