ArticlebioRxiv : the preprint server for biology2025
Eukaryotic Lagging Strand Synthesis is Distributive.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
2 authors.
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Abstract
DNA's anti-parallel structure presents a topological challenge to the replisome, as the leading and lagging strands must be synthesized in opposite directions. It is widely believed that the lagging strand polymerases Pol δ and Pol α are stably tethered to the eukaryotic replisome to facilitate their recycling and to coordinate leading and lagging strand synthesis. To test this idea, we directly visualized the dynamics of Pol α/δ at active replication forks via single-molecule imaging in
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Registered trials
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