ArticlebioRxiv : the preprint server for biology2025
Cytokinetic abscission failures in a polarized epithelium affect apical membrane size and cilia.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cytokinetic abscission is the last step of cell division, during which the intercellular bridge between daughter cells is severed. While abscission genes are linked to cancers and developmental disorders, the consequences of disrupted abscission in vivo have remained under-explored. For a polarized epithelium to expand or renew, cells within it must divide while maintaining polarity, cell junctions, and epithelial integrity. They undergo a polarized form of cytokinesis in which abscission occurs at the apical membrane. Here, we investigate how stochastic abscission failures in a polarized epithelium disrupt epithelial architecture, using mouse neuroepithelium as a model. Previously we showed that in the forebrain of
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