Evidence map›Paper›PMID 41000940›Full record

ArticlebioRxiv : the preprint server for biology2025

The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers.

Bruna V Eckhardt, Hannah J Richter, Inge Rondeel, Keerthi Renduchintala, Francesca Mattiroli, Vijay Ramani

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bruna V EckhardtHubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, NL.
Hannah J RichterGladstone Institute for Data Science and Biotechnology, J David Gladstone Institutes, San Francisco, CA USA.
Inge RondeelHubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, NL.
Keerthi RenduchintalaGladstone Institute for Data Science and Biotechnology, J David Gladstone Institutes, San Francisco, CA USA.
Francesca MattiroliHubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, NL.ORCID 0000-0002-1574-7217
Vijay RamaniGladstone Institute for Data Science and Biotechnology, J David Gladstone Institutes, San Francisco, CA USA.

Funding

SINGLE-CELL CHEMICAL TRANSCRIPTOMIC DISSECTION OF AN ESSENTIAL TRANSCRIPTION FACTOR NETWORKDP2HG012442 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RAMANI, VIJAY · 2021 to 2024
$2.6M
NHGRI NIH HHS DP2 HG012442
6 · The paper itself

Abstract

DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains unknown, as visualizing this short-lived state in cells is impossible. To circumvent this limitation, we combine

Identifiers

PMID41000940
PMCPMC12458411

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.