ArticlebioRxiv : the preprint server for biology2025
CYB5R4 sustains endothelial proliferation and ischemia-induced angiogenesis by maintaining RRM2-dependent nucleotide balance.
Shuai Yuan, Scott A Hahn, Nicole C Colussi, Steven J Mullett, Stacy L Gelhaus, Francisco J Schopfer, Adam C Straub
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Shuai YuanDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-9590-6555 Scott A HahnDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Nicole C ColussiDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Steven J MullettDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Stacy L GelhausDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-9083-6933 Francisco J SchopferDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Adam C StraubDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-0542-9466 Funding
Basic and Translational Studies in Redox Regulation of Cardiovascular Physiology and DiseaseR35HL161177 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Adam Carl Straub · 2022 to 2026
$4.7MFormation and metabolism of nitrated fatty acidsR01GM125944 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCHOPFER, FRANCISCO JOSE · 2018 to 2025
$3.4MImpact of dietary lipid components on phototherapy used to treat inflammatory skin conditionsR01AR084311 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALICIA R MATHERS, Francisco Jose Schopfer · 2025 to 2026
$1.3MAn Exploris 240 for MetabolomicsS10OD032141 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GELHAUS, STACY LYNN · 2022 to 2022
$600kBridging the gap of endogenous nitro-conjugated linoleic acid formation and signalingF31HL172595 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COLUSSI, NICOLE · 2024 to 2025
$89kNHLBI NIH HHS F31 HL172595NHLBI NIH HHS R35 HL161177NIAMS NIH HHS R01 AR084311NIGMS NIH HHS R01 GM125944NIH HHS S10 OD032141
6 · The paper itselfAbstract
Angiogenesis is essential for revascularization in peripheral artery disease (PAD), yet pro-angiogenic therapies remain inconsistent. Here, we identify a cytosolic reductase, CYB5R4, as an intrinsic regulator of endothelial proliferation and ischemia-induced angiogenesis. In mice, global haploinsufficiency or inducible endothelial deletion of
Identifiers
PMID41000936
PMCPMC12458458
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