In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors.
Marshall G LougeeDepartment of Chemistry; School of Arts and Sciences, University of Pennsylvania; 231 South 34th Street, Philadelphia, PA 19104, USA.ORCID 0000-0002-4351-9908 Grace S H ParkBiochemistry, Biophysics, and Chemical Biology Graduate Group; Perelman School of Medicine, University of Pennsylvania; 206 Anatomy-Chemistry Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.ORCID 0009-0005-6899-5053 Hee Jong KimBiochemistry, Biophysics, and Chemical Biology Graduate Group; Perelman School of Medicine, University of Pennsylvania; 206 Anatomy-Chemistry Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.
Jiya Z FowlerBiochemistry, Biophysics, and Chemical Biology Graduate Group; Perelman School of Medicine, University of Pennsylvania; 206 Anatomy-Chemistry Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.ORCID 0000-0001-7216-6497 Zongtao LinDepartment of Biochemistry and Molecular Biophysics; Washington University in St. Louis; 4523 Clayton Ave, St. Louis, MO 63130, USA.ORCID 0000-0002-6017-338X Hossein FazeliniaCHOP-Penn Proteomics Core; Perelman School of Medicine, University of Pennsylvania; 3615 Civic Center Blvd, Philadelphia, PA 19104, USA.
Lynn SpruceCHOP-Penn Proteomics Core; Perelman School of Medicine, University of Pennsylvania; 3615 Civic Center Blvd, Philadelphia, PA 19104, USA.
Evan YanagawaDepartment of Chemistry; School of Arts and Sciences, University of Pennsylvania; 231 South 34th Street, Philadelphia, PA 19104, USA.
Benjamin A GarciaDepartment of Biochemistry and Molecular Biophysics; Washington University in St. Louis; 4523 Clayton Ave, St. Louis, MO 63130, USA.ORCID 0000-0003-3596-4750 Melike LakadamyaliDepartment of Biochemistry and Biophysics; Perelman School of Medicine, University of Pennsylvania; 421 Curie Boulevard, Philadelphia, PA 19104, USA.ORCID 0000-0002-7524-6414 E James PeterssonDepartment of Chemistry; School of Arts and Sciences, University of Pennsylvania; 231 South 34th Street, Philadelphia, PA 19104, USA.ORCID 0000-0003-3854-9210 Funding
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7MTraining in Alzheimer’s and Age-Related Neurodegenerative DiseasesT32AG000255 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ALICE S CHEN-PLOTKIN, VIRGINIA M LEE · 1997 to 2026
$12.5MPredoctoral Training at the Chemistry-Biology InterfaceT32GM133398 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Ronen Marmorstein, Ernest James Petersson · 2020 to 2026
$2.4MStudying Aggregation in Neurodegenerative Disease using Synthetic ProteinsRF1NS103873 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI PETERSSON, ERNEST JAMES · 2023 to 2023
$1.8MBruker RapifleX MALDI TOF/TOF Mass SpectrometerS10OD030460 · OD · UNIVERSITY OF PENNSYLVANIA · PI PETERSSON, ERNEST JAMES · 2021 to 2021
$881kComputational Resource for Structural Biology and Molecular BiophysicsS10OD023592 · OD · UNIVERSITY OF PENNSYLVANIA · PI SHARP, KIM A · 2017 to 2017
$402kNIA NIH HHS P30 AG066444NIA NIH HHS T32 AG000255NIGMS NIH HHS T32 GM133398NIH HHS S10 OD023592NIH HHS S10 OD030460NINDS NIH HHS RF1 NS103873
6 · The paper itselfAbstract
Fibrillar aggregates of the natively disordered protein α-synuclein (αS) are hallmarks of Parkinson's disease and related neurodegenerative disorders termed synucleinopathies. Here, we used micromap (μMap) photo-proximity labeling to determine the interactomes of αS monomers and fibrils in mouse brain lysate to better understand both the loss of healthy function and gain of toxic function aspects of synucleinopathies. Several αS variants were synthesized and characterized, showing that the small size (1 kDa) of the Ir catalyst attached through a Cys-maleimide linkage makes it minimally-perturbing to αS, with a narrow labeling radius that allows one to identify interactome differences between different regions of αS. Monomer and fibril interactomes were compared to each other and to previous proximity labeling data sets for validation and several examples of further investigations are demonstrated, including Western blotting, super-resolution microscopy, and μMap in primary neurons.
Identifiers
PMID41000923
PMCPMC12458157
What OpenQuestion holds
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LicenceCC BY
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