Evidence map›Paper›PMID 41000915›Full record

ArticlebioRxiv : the preprint server for biology2025

Anatomical integrity of the human cochlea estimated with optical coherence tomography for future clinical application.

Paul Secchia, Christopher I McHugh, Nam Hyun Cho, Jennifer T O'Malley, MengYu Zhu, Anbuselvan Dharmarajan, Aleksandrs Zosuls, Jingxin Jessica Feng, Yew Song Cheng, Sunil Puria and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Paul SecchiaProgram in Speech and Hearing Bioscience and Technology, Harvard University, Boston, MA, USA.ORCID 0000-0002-8075-1757
Christopher I McHughEaton-Peabody Laboratories, Department of Otolaryngology-Head and Neck Surgery, Mass Eye and Ear, Boston, MA, USA.ORCID 0000-0001-8343-7934
Nam Hyun ChoEaton-Peabody Laboratories, Department of Otolaryngology-Head and Neck Surgery, Mass Eye and Ear, Boston, MA, USA.ORCID 0000-0002-7188-0565
Jennifer T O'MalleyEaton-Peabody Laboratories, Department of Otolaryngology-Head and Neck Surgery, Mass Eye and Ear, Boston, MA, USA.
MengYu ZhuEaton-Peabody Laboratories, Department of Otolaryngology-Head and Neck Surgery, Mass Eye and Ear, Boston, MA, USA.
Anbuselvan DharmarajanEaton-Peabody Laboratories, Department of Otolaryngology-Head and Neck Surgery, Mass Eye and Ear, Boston, MA, USA.
Aleksandrs ZosulsEaton-Peabody Laboratories, Department of Otolaryngology-Head and Neck Surgery, Mass Eye and Ear, Boston, MA, USA.ORCID 0000-0001-6769-3460
Jingxin Jessica FengEaton-Peabody Laboratories, Department of Otolaryngology-Head and Neck Surgery, Mass Eye and Ear, Boston, MA, USA.
Yew Song ChengEaton-Peabody Laboratories, Department of Otolaryngology-Head and Neck Surgery, Mass Eye and Ear, Boston, MA, USA.ORCID 0000-0002-5746-1639
Sunil PuriaProgram in Speech and Hearing Bioscience and Technology, Harvard University, Boston, MA, USA.ORCID 0000-0002-2810-3541
Andreas H EckhardProgram in Speech and Hearing Bioscience and Technology, Harvard University, Boston, MA, USA.ORCID 0000-0002-4921-6043
Hideko Heidi NakajimaProgram in Speech and Hearing Bioscience and Technology, Harvard University, Boston, MA, USA.ORCID 0000-0002-1377-1934

Funding

TRAINING FOR SPEECH AND HEARING SCIENCEST32DC000038 · NIDCD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Gwenaelle S Geleoc · 1992 to 2026
$21.8M
Mechanics of Human Middle & Inner Ear: Basic Science & Clinical ApplicationR01DC013303 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI NAKAJIMA, HIDEKO HEIDI · 2013 to 2024
$4.5M
RESEARCH TRAINING IN OTOLARYNGOLOGYT32DC000020 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI JUNG, DAVID H, SIMONYAN, KRISTINA · 1990 to 2025
$2.4M
Human otopathology without invading the cochlea imaged using optical coherence tomography and verified with novel histological techniqueF31DC022795 · NIDCD · HARVARD MEDICAL SCHOOL · PI Paul Secchia · 2025 to 2026
$76k
NIDCD NIH HHS F31 DC022795NIDCD NIH HHS R01 DC013303NIDCD NIH HHS T32 DC000020NIDCD NIH HHS T32 DC000038
6 · The paper itself

Abstract

The human cochlea is encased within the otic capsule, the densest bone in the body, posing significant challenges for anatomical imaging of cochlear structures. Because of difficult access and fragility of cochlear structures, our understanding of intracochlear anatomy has historically relied on postmortem histology. We thus have a limited understanding of human cochlear anatomy in its native, unfixed state. Clinical diagnostics for hearing loss, such as audiometry and otoacoustic emissions, offer functional assessments but fail to elucidate the often diverse underlying structural pathologies with any degree of precision. To address the critical need for assessing the human cochlear anatomy and associated pathologies without the risk of traumatizing cochlear structures, we imaged fresh cochleae

Identifiers

PMID41000915
PMCPMC12458443

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.