Evidence map›Paper›PMID 41000891›Full record

ArticlebioRxiv : the preprint server for biology2025

High-resolution, genotype-free mapping of genetic variation with CRI-SPA-Map.

Sheila Lutz, Megan Lawler, Samuel Amidon, Frank W Albert

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Sheila LutzDepartment of Genetics, Cell Biology, & Development, University of Minnesota, Minneapolis, MN 55455, USA.
Megan LawlerDepartment of Genetics, Cell Biology, & Development, University of Minnesota, Minneapolis, MN 55455, USA.
Samuel AmidonDepartment of Genetics, Cell Biology, & Development, University of Minnesota, Minneapolis, MN 55455, USA.
Frank W AlbertDepartment of Genetics, Cell Biology, & Development, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-1380-8063

Funding

Genomic approaches for dissecting regulatory variationR35GM124676 · NIGMS · UNIVERSITY OF MINNESOTA · PI Frank Wolfgang Albert · 2017 to 2026
$4.6M
NIGMS NIH HHS R35 GM124676
6 · The paper itself

Abstract

Genetic variation within species shapes phenotypes, but identifying the specific genes and variants that cause phenotypic differences is costly and challenging. Here, we introduce CRI-SPA-Map, a genetic mapping strategy combining CRISPR-Cas9 genome engineering, selective ploidy ablation (SPA), and high-throughput phenotyping for precise genetic mapping with or without genotyping in the yeast

Identifiers

PMID41000891
PMCPMC12458176

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.