ArticlebioRxiv : the preprint server for biology2025
A cross model spatial and single-cell atlas reveals the conserved involvement of osteopontin in polycystic kidney disease.
Abstract readPreprint
In one paragraph
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
30 authors.
Sarah J MillerDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.ORCID 0000-0003-4888-5306
Hua ZhongDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Weidong WuDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Audrey M CordovaDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Morgan E SmithDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Alex YashchenkoDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Zhang LiDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
Daniyal J JafreeDevelopmental Biology & Cancer Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, UCL, London, UK.ORCID 0000-0001-8235-0394
Chelsea N ZimmermanDepartment of Pediatrics, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA.
Christa I DeVetteDepartment of Pediatrics, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA.
Vicki DoDivision of Nephrology, Boston Children's Hospital, Boston, MA, United States.
Maya HigniteDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Isabella G DarbyDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Khalecha Bintha AhmedDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Yohan ParkDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Fariha NusratDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Bibi MaryamDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Sizhao LuDepartment of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.
Xiaoyan LiDepartment of Internal Medicine, Mayo Clinic, Rochester MN 55905, USA.
Jenny R GipsonCollege of Medicine Core Facilities, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Xiaogang LiDepartment of Internal Medicine, Mayo Clinic, Rochester MN 55905, USA.
David A LongDevelopmental Biology & Cancer Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, UCL, London, UK.ORCID 0000-0001-6580-3435
Mary Weiser-EvansDepartment of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.
Bradley K YoderDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
Benjamin D CowleyDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Katharina HoppDepartment of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.
Jason StubbsThe Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA.
Qin MaDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Anjun MaDepartment of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Kurt A ZimmermanDepartment of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA.
Funding
UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3MROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5MInjury Response Mediated Pathogenesis in Renal CiliopathiesR01DK115752 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Bradley K. Yoder · 2018 to 2026
$4.0MTargeting kidney resident macrophage niche filling to slow cystic kidney diseaseR01DK129255 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Kurt A Zimmerman · 2022 to 2026
$1.6MInvestigating CD4 T regulatory cells during rapid cystogenesisK01DK119375 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZIMMERMAN, KURT A · 2020 to 2023
$608k5-Laser Cytek Aurora Spectral Flow CytometerS10OD028479 · OD · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI THOMPSON, LINDA F · 2020 to 2020
$317kConstructing Mouse and Human Single-cell Atlas in Autosomal Dominant Polycystic Kidney DiseaseR21DK140693 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MA, ANJUN, ZIMMERMAN, KURT A · 2024 to 2024
$136kNIAMS NIH HHS P30 AR048311NIDDK NIH HHS K01 DK119375NIDDK NIH HHS P30 DK079337NIDDK NIH HHS R01 DK115752NIDDK NIH HHS R01 DK129255NIDDK NIH HHS R21 DK140693NIH HHS S10 OD028479Wellcome Trust
Abstract
Polycystic kidney disease (PKD) arises from mutations in cilia-associated genes, such as
Indexed as
macrophagesosteopontinPolycystic kidney diseasesingle cell RNA sequencingspatial transcriptomics
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.