Evidence map›Paper›PMID 41000876›Full record

ArticlebioRxiv : the preprint server for biology2025

Kidney kallikrein-1 contributes to cleavage of gamma-ENaC

Joshua Curry, Xiao Tong Su, Qi Wu, Yujiro Maeoka, Chao-Ling Yang, Eric Delpire, Robert A Fenton, Paul A Welling, David H Ellison

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Joshua CurryDivision of Nephrology & Hypertension, Department of Medicine, OHSU, Portland, OR, USA.ORCID 0000-0002-7364-964X
Xiao Tong SuDivision of Nephrology & Hypertension, Department of Medicine, OHSU, Portland, OR, USA.
Qi WuDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Yujiro MaeokaDepartment of Nephrology, Ichiyokai Harada Hospital, Hiroshima, Japan.
Chao-Ling YangDivision of Nephrology & Hypertension, Department of Medicine, OHSU, Portland, OR, USA.
Eric DelpireDepartment of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Robert A FentonDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Paul A WellingDepartment of Medicine and Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
David H EllisonDivision of Nephrology & Hypertension, Department of Medicine, OHSU, Portland, OR, USA.

Funding

WNK-SPAK signaling in the Distal NephronR01DK093501 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, Paul A Welling · 2012 to 2026
$12.1M
Training in Translational Science and Cardiovascular MedicineT32HL094294 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALKAYED, NABIL J · 2009 to 2018
$3.5M
Role of Kir4.1 in regulating NCC and ROMK in DCTR01DK133220 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID HOADLEY, WANG, WENHUI · 2022 to 2025
$2.6M
NHLBI NIH HHS T32 HL094294NIDDK NIH HHS R01 DK093501NIDDK NIH HHS R01 DK133220
6 · The paper itself

Abstract

The epithelial sodium channel (ENaC) is essential for sodium reabsorption and potassium homeostasis in the distal nephron, where its activity is controlled by mineralocorticoid signaling and downstream proteolytic processing of channel subunits. While cleavage of the γ-ENaC subunit has been implicated in aldosterone-mediated sodium transport, the identity of mineralocorticoid receptor (MR)-regulated proteases responsible for this process remains uncertain. Here, we investigated the role of kallikrein-1 (encoded by

Indexed as

aldosteroneepithelial sodium channelkallikreinpotassium

Identifiers

PMID41000876
PMCPMC12458360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.