Evidence map›Paper›PMID 41000871›Full record

ArticlebioRxiv : the preprint server for biology2025

Exploring metalloproteome remodeling in calprotectin-stressed

Maximillian K Osterberg, Daniel W Bak, Claudia Andreini, Jeanette M Critchlow, Jonathan C Trinidad, Peter V Cornish, Tae Akizuki, Walter J Chazin, Eric P Skaar, Eranthie Weerapana and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Maximillian K OsterbergDepartment of Chemistry, Indiana University, Bloomington, IN 47405-7102 United States.
Daniel W BakDepartment of Chemistry, Boston College, Chestnut Hill, MA 02467-3860 United State.ORCID 0000-0002-2252-1718
Claudia AndreiniMagnetic Resonance Centre (CERM), University of Florence, Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0003-4329-8225
Jeanette M CritchlowDepartment of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, United States.
Jonathan C TrinidadLaboratory for Biological Mass Spectrometry, Department of Chemistry, Indiana University, Bloomington, IN 47405-7102 United States.
Peter V CornishDepartment of Biochemistry, University of Missouri, Columbia, Missouri 65211, United States.
Tae AkizukiDepartments of Biochemistry and of Chemistry, and Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, United States.
Walter J ChazinDepartments of Biochemistry and of Chemistry, and Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, United States.ORCID 0000-0002-2180-0790
Eric P SkaarDepartment of Pathology, Microbiology, and Immunology, and Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, United States.
Eranthie WeerapanaDepartment of Chemistry, Boston College, Chestnut Hill, MA 02467-3860 United States.
David P GiedrocDepartment of Chemistry, Indiana University, Bloomington, IN 47405-7102 United States.ORCID 0000-0002-2342-1620

Funding

Host-mediated zinc sequestration during Acinetobacter baumannii infectionR01AI101171 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALTER J. CHAZIN, DAVID P. GIEDROC · 2013 to 2026
$8.2M
Neisseria gonorrhoeae metal transporters that subvert nutritional immunityR01AI127793 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CYNTHIA N CORNELISSEN, Alison K Criss · 2017 to 2026
$6.8M
Transition Metal Homeostasis and Reactive Sulfur Species in Bacterial PathogensR35GM118157 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI DAVID P. GIEDROC · 2016 to 2026
$5.9M
Developing chemical-proteomic tools to investigate cysteine oxidationR35GM134964 · NIGMS · BOSTON COLLEGE · PI WEERAPANA, ERANTHIE · 2020 to 2024
$3.1M
Graduate Training Program in Quantitative and Chemical Biology at Indiana University BloomingtonT32GM131994 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI JARED C LEWIS · 2019 to 2026
$2.4M
NIAID NIH HHS R01 AI101171NIAID NIH HHS R01 AI127793NIGMS NIH HHS R35 GM118157NIGMS NIH HHS R35 GM134964NIGMS NIH HHS T32 GM131994
6 · The paper itself

Abstract

The growth of bacterial pathogens is limited by nutritional immunity, where the infected host deploys metal scavenging proteins to starve the pathogen of essential transition metals. An important transition metal-sequestering protein is the S100A8-S100A9 heterotetramer, calprotectin (CP). Prior work reveals that CP induces a significant Zn- and Fe-starvation response in the Gram-negative opportunistic pathogen,

Identifiers

PMID41000871
PMCPMC12458113

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.