Evidence map›Paper›PMID 41000870›Full record

ArticlebioRxiv : the preprint server for biology2025

Vascular Patterning affects Intramembranous Ossification through HIF1α-Vegf Signaling.

Soma Dash, Jonathan R Rettig, Madelaine Gogol, Paul A Trainor

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Soma DashDepartment of Biological Sciences, University at Albany, SUNY Albany.ORCID 0000-0002-9030-3341
Jonathan R RettigDepartment of Biological Sciences, University at Albany, SUNY Albany.ORCID 0009-0006-6233-8148
Madelaine GogolStowers Institute for Medical Research.
Paul A TrainorStowers Institute for Medical Research.ORCID 0000-0003-2774-3624

Funding

Functional Characterization of Mediator Complex Proteins in Neural Crest and Craniofacial DevelopmentR00DE030972 · NIDCR · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI DASH, SOMA · 2023 to 2025
$743k
Zeiss LSM 980 Confocal Microscope SystemS10OD028600 · OD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI VALM, ALEX M · 2022 to 2022
$477k
Functional Characterization of Mediator Complex Proteins in Neural Crest and Craniofacial DevelopmentK99DE030972 · NIDCR · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI DASH, SOMA · 2022 to 2023
$200k
NIDCR NIH HHS K99 DE030972NIDCR NIH HHS R00 DE030972NIH HHS S10 OD028600
6 · The paper itself

Abstract

Organs and tissues develop in close association with vasculature which transports blood and nutrients and helps to remove waste. The vasculature is composed primarily of endothelial cells, which provide structure, form barriers, and are a source of developmental signals. We recently found that the Mediator, a multiprotein complex, which regulates transcription, was essential for proper vascular development. Here, we investigated the specific role of the Mediator tail subunit Med23 in endothelial cells. Endothelial specific knockout of

Indexed as

Craniofacial DevelopmentMediator complexSpatial transcriptomicsVascular development

Identifiers

PMID41000870
PMCPMC12458953

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.