ArticlebioRxiv : the preprint server for biology2025
Long-acting naltrexone restores network connectivity in subjects with co-morbid cannabis and opioid use disorder.
Lindsey M Brier, Daniel D Langleben, Corinde E Wiers, Zhenhao Shi
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
4 authors.
Lindsey M BrierCenter for Studies of Addiction Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1831-4935 Daniel D LanglebenCenter for Studies of Addiction Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Corinde E WiersCenter for Studies of Addiction Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-2934-8794 Zhenhao ShiCenter for Studies of Addiction Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5697-2034 Funding
Brain and behavioral effects of graphic cigarette warning labelsR01DA036028 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI LANGLEBEN, DANIEL D · 2013 to 2017
$2.9MEducating Physician Scientists in Psychiatry (EPSP): Firing up the next generation of translational and clinical neuroscientistsR25MH119043 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Mariella De Biasi, MATTHEW S KAYSER · 2019 to 2026
$1.6MKetone-sup before Pub: Effects of ketone supplementation on brain energetics and alcohol consumption in alcohol use disorderR01AA031570 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI Corinde E Wiers · 2025 to 2026
$1.1MMultivariate Modeling of the Neural Mechanisms of Treatment Response in Opioid AddictionK01DA051709 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI SHI, ZHENHAO · 2021 to 2025
$916kModulation of alcohol sensitivity and alcohol tolerance by exogenous ketones in humansR33AA031088 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI Ravi Prakash Reddy Nanga, Corinde E Wiers · 2026 to 2026
$796kModulation of alcohol sensitivity and alcohol tolerance by exogenous ketones in humansR21AA031088 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI NANGA, RAVI PRAKASH REDDY, WIERS, CORINDE E · 2024 to 2025
$421kKetone supplementation as an intervention to alleviate alcohol withdrawal and improve brain energetics in Alcohol Use DisorderR21AA031337 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI NANGA, RAVI PRAKASH REDDY, WIERS, CORINDE E · 2024 to 2025
$376kNIAAA NIH HHS R01 AA031570NIAAA NIH HHS R21 AA031088NIAAA NIH HHS R21 AA031337NIAAA NIH HHS R33 AA031088NIDA NIH HHS K01 DA051709NIDA NIH HHS R01 DA036028NIMH NIH HHS R25 MH119043
6 · The paper itselfAbstract
Co-morbid substance use disorders (
Indexed as
Alcohol use disorderCannabis use disorderCocaine use disorderfMRIFunctional connectivityNaltrexone
Identifiers
PMID41000850
PMCPMC12458199
What OpenQuestion holds
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