Evidence map›Paper›PMID 41000836›Full record

ArticlebioRxiv : the preprint server for biology2025

Lipoxin B

Matangi Kumar, Shruthi Karnam, Shubham Maurya, Rama Nagireddy, John G Flanagan, Karsten Gronert

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Matangi KumarVision Science Graduate Group, University of California Berkeley, Berkeley, CA, United States.
Shruthi KarnamHerbert Wertheim School of Optometry and Vision Science, University of California Berkeley, Berkeley, CA, United States.
Shubham MauryaHerbert Wertheim School of Optometry and Vision Science, University of California Berkeley, Berkeley, CA, United States.
Rama NagireddyHerbert Wertheim School of Optometry and Vision Science, University of California Berkeley, Berkeley, CA, United States.
John G FlanaganVision Science Graduate Group, University of California Berkeley, Berkeley, CA, United States.
Karsten GronertVision Science Graduate Group, University of California Berkeley, Berkeley, CA, United States.

Funding

UC Berkeley Vision Science COREP30EY003176 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Xiaohua Gong · 1985 to 2026
$16.4M
TRAINING PROGRAM IN VISION SCIENCET32EY007043 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Suzanne MJ FLEISZIG · 1985 to 2026
$12.9M
Homeostatic Role and Therapeutic Potential of the Neuroprotective Retinal Lipoxin CircuitR01EY030218 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI FLANAGAN, JOHN G, GRONERT, KARSTEN · 2020 to 2024
$2.4M
NEI NIH HHS P30 EY003176NEI NIH HHS R01 EY030218NEI NIH HHS T32 EY007043
6 · The paper itself

Abstract

Purpose: Müller glia play dual roles in glaucoma, contributing to both retinal homeostasis and neuroinflammation; their activation by elevated intraocular pressure through the mechanosensitive channel TRPV4 promotes a reactive state that drives retinal ganglion cell (RGC) loss. Lipoxin B Methods: Ocular hypertension (OHT) was induced in mice via a silicone oil model, and reactive Müller glia were isolated via magnetic sorting for transcriptomic analysis. Results: RNA bulk-sequencing analysis and qPCR revealed that Müller glia express both 5- and 15-lipoxygenase. Lipidomic analysis confirmed that the lipoxin pathway is functional and that Müller glia endogenously produce LXB Conclusion: Müller glia are a significant source of LXB

Indexed as

GlaucomaGlial cellsLipid mediatorsLipoxinsNeurodegenerationNeuroinflammationRetina

Identifiers

PMID41000836
PMCPMC12458309

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.