Evidence map›Paper›PMID 41000702›Full record

ArticlebioRxiv : the preprint server for biology2025

The circadian regulator PER1 inhibits osteoclastogenesis by activating inflammatory genes.

Nobuko Katoku-Kikyo, Elizabeth K Vu, Samuel Mitchell, Ismael Y Karkache, Elizabeth W Bradley, Nobuaki Kikyo

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Nobuko Katoku-KikyoStem Cell Institute, University of Minnesota.
Elizabeth K VuStem Cell Institute, University of Minnesota.
Samuel MitchellStem Cell Institute, University of Minnesota.
Ismael Y KarkacheStem Cell Institute, University of Minnesota.
Elizabeth W BradleyStem Cell Institute, University of Minnesota.
Nobuaki KikyoStem Cell Institute, University of Minnesota.

Funding

RNA methylation and mesenchymal stem cell differentiationR01GM137603 · NIGMS · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2020 to 2023
$1.4M
Cellular Mechanisms of Age-Associated Cortical Bone RemodelingR21AR084530 · NIAMS · UNIVERSITY OF MINNESOTA · PI BRADLEY, ELIZABETH W · 2024 to 2024
$375k
NIAMS NIH HHS R21 AR084530NIGMS NIH HHS R01 GM137603
6 · The paper itself

Abstract

Disruption of circadian rhythms predisposes shift workers to many chronic conditions, including osteoporosis. However, the effects of disrupted circadian rhythms on bone remodeling remain largely unknown. Here, we show that one of the core circadian regulators PER1 inhibits osteoclastogenesis by upregulating genes involved in inflammation. The conditional knockout of

Indexed as

Bone masscircadian rhythmsinflammasomeinflammationosteoclastosteoimmunologyPer1

Identifiers

PMID41000702
PMCPMC12458312

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.