In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
19 authors.
Carys WilliamsDivision of Structural Biology, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-4855-4139 Laura M NockaDepartments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-2556-4227 George HedgerSir Ernst Chain Building, South Kensington Campus, Imperial College London, London, UK.ORCID 0009-0002-2499-0662 Pragya ParasharaDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0009-0006-2357-7218 Naomi R LatorracaDepartment of Molecular & Cell Biology, University of California, Berkeley, Berkeley, California, USA.ORCID 0000-0002-8310-8708 Ganesh V PusapatiDepartments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-1406-2566 Dorothy LarteyDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-3655-9987 Lei GaoDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-7043-4774 Ljiljana MilenkovicDepartments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, California, USA.ORCID 0009-0006-9602-4577 Rod ChalkCentre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-9942-2339 Susan MarquseeDepartment of Molecular & Cell Biology, University of California, Berkeley, Berkeley, California, USA.ORCID 0000-0001-7648-2163 Loïc CarriqueDivision of Structural Biology, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0001-5332-8593 Sarah L RouseSir Ernst Chain Building, South Kensington Campus, Imperial College London, London, UK.ORCID 0000-0002-7115-1565 Jennifer H KongDepartment of Biochemistry, School of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-4573-3270 Christian SieboldDivision of Structural Biology, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-6635-3621 Rajat RohatgiDepartments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0001-7609-8858 Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MSupplement application for an Olympus automated microscopeR35GM118082 · NIGMS · STANFORD UNIVERSITY · PI RAJAT ROHATGI · 2016 to 2026
$7.6MA protein traffic control system that regulates left-right patterning and heart developmentR01HL157103 · NHLBI · STANFORD UNIVERSITY · PI GUNN, TERESA M, LO, CECILIA W. · 2021 to 2024
$2.9MSequence and Environmental Determinants of the Protein Energy LandscapeR35GM149319 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SUSAN MARQUSEE · 2023 to 2026
$1.7MMolecular mechanisms that regulate target cell sensitivity to Hedgehog morphogensR00GM132518 · NIGMS · UNIVERSITY OF WASHINGTON · PI KONG, JENNIFER · 2023 to 2025
$871kMolecular mechanisms that regulate target cell sensitivity to Hedgehog morphogensK99GM132518 · NIGMS · STANFORD UNIVERSITY · PI KONG, JENNIFER · 2019 to 2021
$281kDecoding Structural Determinants of Efficacy and Specificity in a GPCR SubfamilyK99GM148823 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LATORRACA, NAOMI · 2023 to 2024
$212kNCI NIH HHS P30 CA015704NHLBI NIH HHS R01 HL157103NIGMS NIH HHS K99 GM132518NIGMS NIH HHS K99 GM148823NIGMS NIH HHS R00 GM132518NIGMS NIH HHS R35 GM118082NIGMS NIH HHS R35 GM149319Wellcome Trust
6 · The paper itselfAbstract
Receptor-type E3 ubiquitin ligases are membrane-spanning assemblies that enable extracellular signals to directly control ubiquitylation in the cytoplasm. Despite playing widespread roles in tissue patterning and homeostasis, metabolism, and immunity, their structures and mechanisms remain poorly understood. Using cryo-electron microscopy, integrated with biophysical and functional studies, we visualized an E3 complex composed of two transmembrane proteins, MEGF8 and MOSMO, and the intracellular RING-family protein MGRN1. This MEGF8-MOSMO-MGRN1 (MMM) complex regulates left-right patterning of the body axis and the development of multiple organs, partly by attenuating signaling through the Hedgehog pathway. We find that the MMM complex functions like a fishing pole: a long, flexible helix attached to a membrane platform suspends an activated and precisely oriented RING domain-like a fishhook-to ubiquitylate the cytoplasmic surfaces of target receptors. Our structure explains how mutations in
Indexed as
birth defectsCarpenter syndromecryo-EM structureE3 ligasemolecular dynamics simulationsmorphogenssignalingtransmembrane receptorubiquitylation
Identifiers
PMID41000701
PMCPMC12458338
What OpenQuestion holds
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