Evidence map›Paper›PMID 41000677›Full record

ArticlebioRxiv : the preprint server for biology2025

A widespread protein misfolding mechanism is differentially rescued by chaperones based on gene essentiality.

Ian Sitarik, Quyen Vu, Justin Petucci, Paulina Frutos, Hyebin Song, Edward P O'Brien

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ian SitarikDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States.ORCID 0000-0001-8553-923X
Quyen VuDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States.
Justin PetucciInstitute for Computational and Data Sciences, Pennsylvania State University, University Park, Pennsylvania, United States.
Paulina FrutosDepartment of Biology, Pennsylvania State University, University Park, Pennsylvania, United States.
Hyebin SongBioinformatics and Genomics Graduate Program, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, United States.
Edward P O'BrienDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States.

Funding

Translation Kinetics and their Effects on Protein Structure and Function, mRNA half-lives, and Cellular PhenotypeR35GM124818 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Edward Patrick O'Brien · 2017 to 2026
$4.0M
NIGMS NIH HHS R35 GM124818
6 · The paper itself

Abstract

Protein misfolding involving changes in non-covalent lasso entanglement (NCLE) status has been proposed based on simulations and biochemical assays of a small number of proteins. Here, we detect hallmarks of these misfolded states across hundreds of proteins by integrating

Identifiers

PMID41000677
PMCPMC12458143

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.