Evidence map›Paper›PMID 41000653›Full record

ArticlebioRxiv : the preprint server for biology2025

Targeting DNA Polymerase Epsilon Leads to Tumor Clearance and Activation of an NF-κB-mediated inflammatory response in Triple Negative Breast Cancer.

Elizabeth F Sher, Kenji M Fujihara, Anthony Tao, Diana Erenburg, Vladislav O Sviderskiy, Hannan Mir, Triantafyllia R Karakousi, Cynthia Loomis, Jiehui Deng, Kwok-Kin Wong and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Elizabeth F SherDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Kenji M FujiharaDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Anthony TaoDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Diana ErenburgDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Vladislav O SviderskiyDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Hannan MirDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Triantafyllia R KarakousiDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Cynthia LoomisDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.
Jiehui DengLaura & Isaac Perlmutter Cancer Center, New York, NY 10016, USA.
Kwok-Kin WongLaura & Isaac Perlmutter Cancer Center, New York, NY 10016, USA.
Richard PossematoDepartment of Pathology, NYU Grossman School of Medicine, New York, USA.

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Functional Relevance of Pyrimidine Sensing and Response Pathways in Tumor Metabolism and Cancer TherapyR01CA286141 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Richard Lewis Possemato · 2024 to 2026
$2.7M
Targeting Metabolic Liabilities in CancerR01CA214948 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI POSSEMATO, RICHARD LEWIS · 2018 to 2022
$1.9M
Regulation Of Metabolism And Gene Expression By Iron-Sulfur Clusters - SupplementR01GM132491 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI POSSEMATO, RICHARD LEWIS · 2020 to 2023
$1.9M
Activation of Inflammatory Responses Upon Replication Stress in Basal-Like Breast CancerF30CA271623 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GORODETSKY, ELIZABETH FRANCES · 2022 to 2025
$213k
Targeting Iron-Sulfur Cluster Biosynthesis for the Treatment of Basal-Like Breast CancerF30CA228202 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SVIDERSKIY, VLADISLAV · 2018 to 2020
$150k
NCI NIH HHS F30 CA228202NCI NIH HHS F30 CA271623NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA214948NCI NIH HHS R01 CA286141NIGMS NIH HHS R01 GM132491
6 · The paper itself

Abstract

Breast cancer remains the second leading cause of cancer-related mortality among women, with triple-negative breast cancer (TNBC) exhibiting a particularly poor five-year prognosis

Identifiers

PMID41000653
PMCPMC12458326

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.