Evidence map›Paper›PMID 41000649›Full record

ArticlebioRxiv : the preprint server for biology2025

Cortical tension as a mechanical barrier to safeguard against premature differentiation during neurogenesis.

Daniel Halperin, Chrystian Junqueira Alves, Marcelle Rodrigues Lemos, Swagata Dey, Haochen Tao, Sangjo Kang, Xianting Li, Zhenyu Yue, Jiaxi Li, Rodrigo Alves Dias and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Daniel HalperinNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-1598-989X
Chrystian Junqueira AlvesNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marcelle Rodrigues LemosDepartment of Physics, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Swagata DeyNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Haochen TaoNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sangjo KangNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Xianting LiDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zhenyu YueNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jiaxi LiNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rodrigo Alves DiasDepartment of Physics, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Gustavo de Oliveira RosaDepartment of Physics, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
José P Rodrigues Furtado de MendonçaDepartment of Physics, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Molly EstillNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yonatan PerezDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Susana I RamosDepartment of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nadejda M TsankovaNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Li ShenNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Roland H FriedelNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-7513-3604
Hongyan ZouNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

Plexin-B2 function in glioma invasion and glioma stem cell maintenanceR01NS092735 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRIEDEL, ROLAND HORST · 2016 to 2025
$4.1M
Generation of Neurons by Force-Mediated Epigenetic Mechanisms through Manipulation of Intrinsic MechanoregulatorsK01NS127948 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JUNQUEIRA ALVES, CHRYSTIAN · 2023 to 2025
$961k
Mechano-Electrical Regulation of NeurogenesisR21NS145550 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JUNQUEIRA ALVES, CHRYSTIAN, ZOU, HONGYAN JENNY · 2025 to 2025
$491k
Novel Mechanisms of Confined Migration of GBM CellsR21NS134158 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRIEDEL, ROLAND HORST · 2024 to 2025
$480k
NINDS NIH HHS K01 NS127948NINDS NIH HHS R01 NS092735NINDS NIH HHS R21 NS134158NINDS NIH HHS R21 NS145550
6 · The paper itself

Abstract

Neuronal differentiation requires coordinated gene reprogramming and morphodynamic remodeling. How mechanical forces integrate with nuclear gene programs during neurogenesis remains unresolved. Here, we identify cortical tension as a mechanical barrier that safeguards against premature neuronal differentiation. Deletion of Plexin-B2, a guidance receptor controlling actomyosin contractility, lowers this barrier, enabling neurite outgrowth and accelerating neuronal lineage commitment. We show that coupling of extrinsic differentiation cues with intrinsic morphodynamics is essential for stabilizing neuronal fate and that cortical barrier and epigenetic barrier act in concert to regulate developmental timing. In cerebral organoids, Plexin-B2 ablation triggered premature cell-cycle exit and differentiation, resulting in progenitor pool depletion and neuroepithelial disorganization, phenotypes echoing intellectual disability in patients with rare pathogenic

Indexed as

Cerebral organoidCortical barrierCorticogenesisInduced neuronNeurodevelopmentNeuronal differentiationPlexin-B2

Identifiers

PMID41000649
PMCPMC12458310

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.