Evidence map›Paper›PMID 41000645›Full record

ArticlebioRxiv : the preprint server for biology2025

H3K27me3 chromatin heterogeneity reveals variable cell responses to estrogen and endocrine treatment.

Fleur Chapus, Christopher R Day, Laura G Kammel, Pelin Yasar, Brian Bennett, Erica Scappini, Charles Tucker, Maria Sifre, Celyn Bregio, Joseph Rodriguez

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fleur ChapusEpigenetics and RNA Biology Laboratory, Single Cell Dynamics Group, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.ORCID 0000-0001-6611-9547
Christopher R DayEpigenetics and RNA Biology Laboratory, Single Cell Dynamics Group, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Laura G KammelEpigenetics and RNA Biology Laboratory, Single Cell Dynamics Group, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Pelin YasarEpigenetics and RNA Biology Laboratory, Single Cell Dynamics Group, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Brian BennettIntegrative Bioinformatics Support Group, Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Erica ScappiniFluorescence Microscopy and Imaging Center, Molecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Charles TuckerFluorescence Microscopy and Imaging Center, Molecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Maria SifreFlow Cytometry Center, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Celyn BregioEpigenetics and RNA Biology Laboratory, Single Cell Dynamics Group, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.
Joseph RodriguezEpigenetics and RNA Biology Laboratory, Single Cell Dynamics Group, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC 27709, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene expression heterogeneity generates subpopulations of tumor cells that can evade therapeutic pressure. This heterogeneity has been observed in both primary Estrogen Receptor alpha positive

Identifiers

PMID41000645
PMCPMC12458927

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.