ArticlebioRxiv : the preprint server for biology2025
Causal role for pulvinar burst firing in thalamo-cortical attention control.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
The primate pulvinar has been implicated in coordinating cortical networks during attention, but its causal role remains elusive. Like other thalamic nuclei, pulvinar neurons switch between tonic and burst firing, but whether bursts influence behavior and cognitive processes is unknown. Here, we show that pulvinar bursts are not only modulated by attention but also predict behavioral performance. In macaques performing a covert attention task, bursts were more frequent for non-cued targets and uniquely reconfigured population codes in parietal cortex. Crucially, electrical microstimulation of pulvinar triggered bursts that enhanced target detection and synchronized cortical spiking, with behavioral benefits scaling with the strength of burst recruitment. These results establish pulvinar bursts as a causal driver of attention, revealing a thalamo-cortical mechanism by which thalamus exerts moment-to-moment control over cortical processing and behavior.
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