Evidence map›Paper›PMID 41000627›Full record

ArticlebioRxiv : the preprint server for biology2025

Life in the fast lane: Functional consequences of male-female dynamic differences in the renal auto-regulation of flow.

Lingyun Ivy Xiong, Alan Garfinkel, Kevin M Bennett, Edwin J Baldelomar, Lauryn Brown, Kate Barrows, Volker Vallon, Aurelie Edwards, Alicia A McDonough, Natalie Porat-Shliom and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lingyun Ivy XiongDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA.ORCID 0000-0003-4594-4120
Alan GarfinkelDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA.
Kevin M BennettMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MI.
Edwin J BaldelomarMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MI.
Lauryn BrownCell Biology and Imaging Section, Thoracic and GI Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Kate BarrowsCell Biology and Imaging Section, Thoracic and GI Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Volker VallonDepartments of Medicine and Pharmacology, University of California, San Diego, CA.
Aurelie EdwardsDepartment of Biomedical Engineering, Boston University, Boston, MA.
Alicia A McDonoughDepartment of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Natalie Porat-ShliomCell Biology and Imaging Section, Thoracic and GI Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-2676-8483
Eric J DeedsDepartment of Integrative Biology and Physiology, University of California, Los Angeles, CA.ORCID 0000-0002-2868-7495

Funding

Mitochondrial metabolism in normal and transformed cellsZIABC011828 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PORAT SHLIOM, NATALIE · 2018 to 2025
$9.4M
Characterizing functional states of macrophages via their stimulus-responsesR01AI173214 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alexander Hoffmann · 2023 to 2026
$2.8M
Developing tools for the unbiased analysis and visualization of scRNA-seq dataR01GM143378 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEEDS, ERIC J · 2021 to 2024
$1.2M
Resting state MRI to map autoregulation of the kidneyR21DK134104 · NIDDK · WASHINGTON UNIVERSITY · PI BENNETT, KEVIN M · 2022 to 2023
$679k
Intramural NIH HHS ZIA BC011828NIAID NIH HHS R01 AI173214NIDDK NIH HHS R21 DK134104NIGMS NIH HHS R01 GM143378
6 · The paper itself

Abstract

Tubuloglomerular feedback (TGF) is essential for the renal auto-regulation of flow. TGF is known to induce spontaneous oscillations in single-nephron tubular fluid flow in male kidneys. However, male-female differences in this dynamic behavior have not been studied. Leveraging intravital two-photon microscopy, resting-state magnetic resonance imaging, ultrasound-based and transdermal recordings, we found TGF-mediated oscillations across spatial scales in the rodent kidney, from single-nephron to whole-organ levels, and that male kidneys exhibited higher operating frequencies than females. To understand the mechanisms involved, we developed a dynamical systems model of TGF that agrees with physiological observations. Analysis of the mathematical model indicated that higher reabsorption rate and fluid flow efficiency in male proximal tubules not only result in higher frequencies, but also render male nephrons more susceptible to lose TGF-mediated oscillations. Furosemide abolished TGF-mediated oscillations in male kidneys and upregulated tubular injury marker KIM-1, suggesting that the propensity to lose TGF-mediated oscillations underlies the heightened risk for injury in males. Our analysis also indicated that SGLT-2 inhibition confers renoprotection by preserving TGF-mediated oscillations in hyperglycemia. Combining quantitative imaging and mathematical modeling, this study provides mechanistic insights into the transition from normal physiology to pathophysiology in the kidney.

Identifiers

PMID41000627
PMCPMC12458117

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.