ArticlebioRxiv : the preprint server for biology2025
Structural analysis of 23S rRNA methylating enzyme Cfr reveals RNA binding determinants for methylation regiospecificity and antibiotic resistance.
Michael Fruci, Annia Rodríguez Hernández, Tatiana Skarina, Lou Ann Verellen, Kaitlyn Tsai, Johanna M Virta, Danica Galonić Fujimori, Alexei Savchenko, Peter J Stogios
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Michael FruciLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, ON, N5V 4T3, Canada.
Annia Rodríguez HernándezDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.
Tatiana SkarinaDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, M5S 1A4, Canada.
Lou Ann VerellenLondon Research and Development Centre, Agriculture and Agri-Food Canada, London, ON, N5V 4T3, Canada.
Kaitlyn TsaiDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.
Johanna M VirtaDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.
Danica Galonić FujimoriDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-4066-9417 Alexei SavchenkoDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, M5S 1A4, Canada.ORCID 0000-0002-5256-9237 Peter J StogiosDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, M5S 1A4, Canada.ORCID 0000-0001-8663-1425 Funding
TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES.75N93022C00035 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SATCHELL, KARLA · 2022 to 2025
$20.7MRadical SAM-dependent methylation in antibiotic resistanceR01AI137270 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Danica Galonic Fujimori · 2018 to 2026
$3.8MResearch Training in Chemistry and Chemical BiologyT32GM145460 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason E Gestwicki · 2022 to 2026
$3.1MNIAID NIH HHS 75N93022C00035NIAID NIH HHS HHSN272201700060CNIAID NIH HHS R01 AI137270NIGMS NIH HHS T32 GM145460
6 · The paper itselfAbstract
The 23S rRNA methylating enzyme Cfr, found in pathogens including
Indexed as
AlphaFoldantimicrobial resistanceantimicrobial susceptibilitycrystallographymass spectrometrymethyltransferaseribosome
Identifiers
PMID41000619
PMCPMC12458371
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