ArticleRSC advances2025
Cu-diamine ligand-controlled asymmetric Henry reactions and their application in concise total syntheses of linezolid and rivaroxaban.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
A Cu-bis(sulfonamide)-diamine complex catalytic system was exploited in asymmetric Henry reactions to construct versatile chiral nitroalcohols with high enantioselectivity from carbamate-acetaldehydes and nitromethane. This elegant approach was further implemented to complete the asymmetric total syntheses of a series of oxazolidone skeleton drugs, such as linezolid (antibiotic) and rivaroxaban (anti-coagulant), in a concise and efficient way.
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Registered trials
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