ArticleFrontiers in cardiovascular medicine2025
TyG index and CBC-derived inflammatory indicators individual and mixed effects on all-cause and cardiovascular disease deaths in patients with CHD.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Association between the systemic inflammation response index and the prognosis of patients with myocardial infarction: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Review
- The systemic immune-inflammation index in coronary heart disease: a narrative review of thromboinflammation, phenotype-dependent utility, and clinical translation.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims: Currently, most epidemiological investigations have concentrated on exploring the correlation between a singular indicator and the risk of cardiovascular disease. In clinical practice, a single indicator often fails to comprehensively represent a patient's health status. Consequently, it is crucial to thoroughly evaluate the influence of multiple indicators on disease prediction. Recently, the Triglyceride-Glucose Index (TyG Index) and inflammatory markers derived from CBC (CBC) have garnered increasing attention. Nevertheless, research on the individual and synergistic impacts of the TyG index and inflammatory indices on the risk of all-cause mortality and cardiovascular death in patients with coronary heart disease (CHD) remains scarce. To develop a more accurate risk assessment instrument for the clinic and to provide a novel strategy and framework for the management of individuals with coronary artery disease (CAD). Methods and results: This study identified patients with CHD aged 20 years and older from five cycles of National Health and Nutrition Examination Survey (NHANES) data spanning 2009 to 2018. We employed weighted logistic regression analysis and the restricted cubic spline (RCS) approach to investigate the TyG index and CBC-derived inflammatory indicators in relation to the risk of all-cause mortality and cardiovascular mortality in patients with CHD. The cumulative exposure effect of these measures was estimated utilizing a Weighted Quantitative Scoring (WQS) model. In the unadjusted model, ln(SII) (OR = 1.8, 95% CI = 1.05 ∼ 3.06, Conclusion: Our investigation demonstrated that the TyG index and inflammatory indices generated from CBC are significant risk factors for all-cause mortality and cardiovascular mortality in patients with CHD, with NPR and SII representing the largest proportion of these factors.
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