ReviewInternational journal of general medicine2025
Application of Acupuncture in Cervical Spondylotic Radiculopathy: An In-Depth Analysis and Outlook on Pathophysiological Basis and Therapeutic Mechanisms.
Review in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Ultrasound-guided brachial plexus hydrodissection combined with acupotomy release for the treatment of cervical spondylotic radiculopathy: a multicenter retrospective study.Frontiers in aging neuroscience · 2026Article
- Data Mining of Acupuncture Prescriptions for Lateral Epicondylitis: A Literature-Based Analysis of Acupoint Patterns and Parameters.Journal of pain research · 2026Article
- Therapeutic modulation of pain-related affective disorders by acupuncture: Mechanistic review.Molecular painReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cervical Spondylotic Radiculopathy (CSR) is a debilitating condition caused by nerve root compression from degenerative cervical changes, leading to pain and dysfunction. Acupuncture, a key non-pharmacological treatment, shows significant clinical promise, yet its biological mechanisms are not fully understood. This article analyzes CSR's pathophysiology and acupuncture's therapeutic actions, based on literature published between 2010 and 2025, with a focus on recent key advancements. The review covers CSR's pathology, including mechanical compression, neuro-inflammation (eg, TNF-α), and neural sensitization. It then elucidates acupuncture's mechanisms: central analgesia via endogenous opioids (eg, β-endorphin), downregulation of pro-inflammatory mediators, enhanced local microcirculation, and modulation of oxidative stress. In conclusion, acupuncture intervenes in CSR's pathology through a multi-target neuro-immune-circulatory network. Future high-quality clinical trials and deeper molecular studies are essential to provide robust scientific evidence for its clinical application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.