ArticleFrontiers in immunology2025
YBX1 modulates humoral immunity through post-transcriptional regulation in B cells.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A single-cell transcriptomic atlas of peripheral blood immune cells spanning progressive canine leishmaniosis.iScience · 2026Article
- Translational Fidelity Decline in the Aging Oocyte and Embryo Development.International journal of molecular sciences · 2026Review
- YBX1 as an adaptive RNA hub in cancer: linking state-dependent RNA regulation to tumor immunity, metabolic reprogramming, and therapy resistance.Frontiers in immunology · 2026Review
- A single-cell transcriptomic atlas of peripheral blood immune cells spanning progressive canine leishmaniosis.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Introduction: Y-box binding protein 1 (YBX1) is a multifunctional RNA- and DNA-binding protein implicated in transcriptional regulation, mRNA stabilization, and translation, as well as cell proliferation and stress responses. Although widely studied in cancer and inflammation, its Methods: To investigate YBX1 function in these contexts, we performed transplantation of fetal liver cells (FLCs) from E14.5 Results: Despite markedly reduced cellularity and progenitor frequencies in Discussion: Mechanistic analyses demonstrated that YBX1 directly binds to immunoglobulin mRNAs and enhances their translation, establishing a post-transcriptional mechanism by which YBX1 supports humoral immunity. Together, these findings reveal an unexpected, non-redundant role for YBX1 in regulating immune effector functions. By enhancing immunoglobulin and myeloid inflammatory mediator mRNA translation, YBX1 emerges as a contributor to immune homeostasis and possibly tumor immune evasion by regulating the expression of immunomodulatory factors in immune and malignant cells alike.
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