Evidence map›Paper›PMID 41000383›Full record

ReviewFrontiers in immunology2025

The role of IL-2 in type 2 immunity.

Naoya Tatsumi, Yosuke Kumamoto

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Naoya TatsumiCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, United States.
Yosuke KumamotoCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ, United States.

Funding

Regulation of Th2 differentiation by skin-resident dendritic cellsR01AI132576 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI YOSUKE KUMAMOTO · 2017 to 2026
$3.8M
Mechanism of cDC2 subset differentiation in peripheral organsR01AI165622 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI YOSUKE KUMAMOTO · 2023 to 2026
$2.9M
Regulation of lung inflammation by crosstalk between dendritic cells and sensory neuronsR21AI180678 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI KUMAMOTO, YOSUKE · 2024 to 2025
$425k
NIAID NIH HHS R01 AI132576NIAID NIH HHS R01 AI165622NIAID NIH HHS R21 AI180678
6 · The paper itself

Abstract

Type 2 immune responses are essential for protective immunity against helminth parasites and for promoting tissue repair, but they can also drive allergic inflammation. T helper type 2 (Th2) cells and group 2 innate lymphoid cells (ILC2s) are key drivers of these responses, producing hallmark type 2 cytokines such as IL-4, IL-5, IL-9 and/or IL-13. While IL-2 has long been recognized as a T cell growth factor, emerging evidence reveals its central role in shaping Th2 cell fate and function. This review focuses on recent studies on how the availability of IL-2 is regulated

Indexed as

Immunity, InnateInterleukin-2Th2 CellsAdaptive ImmunityAnimalsHumansLymphocytesInterleukin-2dendritic cell (DC)IL-2 (interleukin-2)ILC2 - group 2 innate lymphoid cellT helper type 2 (Th2)type 2 immunity

Identifiers

PMID41000383
PMCPMC12457388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.