Evidence map›Paper›PMID 41000371›Full record

ArticleIEEE International Conference on Automation Science and Engineering (CASE) : [proceedings]. IEEE Conference on Automation Science and Engineering2025

Deep Learning-Enhanced Robotic Subretinal Injection with Real-Time Retinal Motion Compensation.

Tianle Wu, Mojtaba Esfandiari, Peiyao Zhang, Russell H Taylor, Peter Gehlbach, Iulian Iordachita

Abstract read
In one paragraph

Article in IEEE International Conference on Automation Science and Engineering (CASE) : [proceedings]. IEEE Conference on Automation Science and Engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. A Deep Learning-Driven Autonomous System for Retinal Vein Cannulation: Validation Using a Chicken Embryo Model.Proceedings of the ... IEEE/RSJ International Conference on Intelligent Robots and Systems. IEEE/RSJ International Conference on Intelligent Robots and Systems · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tianle WuLaboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, MD, USA.
Mojtaba EsfandiariLaboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, MD, USA.
Peiyao ZhangLaboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, MD, USA.
Russell H TaylorLaboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, MD, USA.
Peter GehlbachWilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD, USA.
Iulian IordachitaLaboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, MD, USA.

Funding

Enabling Technology for Safe Robot-assisted Surgical MicromanipulationR01EB023943 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI GEHLBACH, PETER LOUIS, IORDACHITA, IULIAN IOAN · 2017 to 2024
$2.3M
Enabling technology for image-guided robot-assisted sub-retinal injectionsR01EB025883 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI IORDACHITA, IULIAN IOAN · 2019 to 2021
$1.5M
Enabling Dexterous Intraocular Surgery with Robotic AssistanceR01EB034397 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI IULIAN IOAN IORDACHITA · 2024 to 2026
$1.2M
NIBIB NIH HHS R01 EB023943NIBIB NIH HHS R01 EB025883NIBIB NIH HHS R01 EB034397
6 · The paper itself

Abstract

Subretinal injection is a critical procedure for delivering therapeutic agents to treat retinal diseases such as inherited retinal diseases (IRD) and age-related macular degeneration (AMD). However, retinal motion caused by physiological factors such as respiration and heartbeat significantly impacts precise needle positioning, increasing the risk of retinal pigment epithelium (RPE) damage. This paper presents a fully autonomous robotic subretinal injection system that integrates intraoperative optical coherence tomography (iOCT) imaging and deep learning-based motion prediction to synchronize needle and retinal motion. A Long Short-Term Memory (LSTM) neural network is used to predict internal limiting membrane (ILM) motion, outperforming a Fast Fourier Transform (FFT)-based baseline model. Additionally, a real-time registration framework aligns the needle tip position with the robot's coordinate frame. Then, a dynamic proportional speed control strategy ensures smooth and adaptive needle insertion. Experimental validation in both simulation and

Identifiers

PMID41000371
PMCPMC12459653

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.