ArticleJournal of Alzheimer's disease reports
Regular monitoring of SARS-CoV-2 carriage and antibody levels against the virus helped maintain social interactions for Alzheimer's disease residents in a Belgian nursing home during the pandemic.
Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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23 authors.
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Abstract
Background: People suffering from Alzheimer's disease and related disorders (ADRD) were severely impacted by the COVID-19 pandemic, both physically and mentally. Objective: This one-year study aimed to implement a protocol for controlling the spread of SARS-CoV-2 in a Belgian nursing home hosting exclusively patients suffering from ADRD, while minimizing pandemic-associated constraints. Methods: After confirming the absence of positive cases in the nursing home and the development of a proper immunity against SARS-CoV-2, the staff members enrolled in the study were allowed to remove their mask. Then, a weekly non-invasive saliva RT-qPCR testing for SARS-CoV-2 detection was implemented to detect cases among the staff and residents. A monthly serological monitoring was set up to follow the levels of neutralizing and IgG antibodies against SARS-CoV-2. Results: Three waves of COVID-19 infection were observed and quickly contained thanks to an effective quarantine policy. We confirmed the stronger humoral response developed by people infected before primo-vaccination compared to naïve-vaccinated ones and the weaker immune response of elderly individuals compared to younger participants, a difference abolished by booster. In parallel, we showed that ADRD people were able to develop a similar humoral response to SARS-CoV-2 vaccination or infection to that of people of similar age not suffering from these diseases. Conclusions: We show that a strict protocol aimed at early case detection and anti-SARS-CoV-2 immunity follow-up has enabled ADRD residents from a Belgian nursing home to maintain social interactions thanks to the ability of study participants to remove masks, while minimizing the risk of infection.
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