ArticleFrontiers in public health2025
Global, regional, and national time trends in disability-adjusted life years for neonatal preterm birth, from 1992 to 2021: an age-period-cohort analysis for the global burden of disease study 2021.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neonatal preterm birth emerges as a leading cause of neonatal mortality and morbidity. Although there is a growing recognition of the urgent need to address the global health challenges posed by neonatal preterm birth, the underlying causes behind the complex and multidimensional trends contributing to its burden, as well as potential intervention pathways, remain unclear. We aim to characterize and deeply analyze the global, regional, and national neonatal preterm birth burden and their trends from 1992 to 2021. Methods: Data on the number, all-age rate, age-standardized rate (ASR), and the relative change of neonatal preterm birth disability-adjusted life years (DALYs) were obtained from the Global Burden of Disease Study (GBD) 2021. Correlations of ASR with Socio-demographic Index (SDI) were evaluated by Spearman's rank correlation analyses. Furthermore, age-period-cohort modeling was used to estimate the net drift (overall annual percentage change), local drift (age-specific annual percentage change), age, period, and cohort effects over the past three decades. Results: Globally, the number of neonatal preterm birth DALYs decreased by 34.0% from 121,633 in 1992 to 80,335 in 2021, and the ASR in 2021 was 1254.24 per 100,000 population, representing a reduction of 35.2% from 1992. The net drift ranged from 0.257% for high SDI region to 1.382% for low SDI region. A negative correlation was observed between ASR and SDI in 2021 at national levels. There has been a transition of DALYs from the neonatal population to older age groups (≥5 years) from 1992 to 2021. Regions and countries exhibited similar age-effect patterns, with decreasing risk with increasing age, and varying period and cohort effects. Conclusion: The global burden of neonatal preterm birth showed an overall declining trend from 1992 to 2021, but persistent health inequalities between regions and countries were driven by socioeconomic disparities. Neonatal preterm birth remains a crucial issue in children, and its growing long-term impact must not be overlooked. Each country presents unique trends, and tailored public health strategies in different settings are critical to managing the burden of preterm neonatal birth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.