Evidence map›Paper›PMID 41000236›Full record

ArticleJournal of oral microbiology2025

Microbiome differences between trauma- and caries-derived periapical lesions using next-generation sequencing.

Jiyuan Zhan, Yinxue Huang, Xinhui Meng, Yiquan Wang, Jia Liang, Fengjiao Zhu, Rui She, Shanshan Huang, Lijun Huo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiyuan ZhanYunnan Key Laboratory of Stomatology & Department of Cariology, Operative Dentistry and Endodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, China.
Yinxue HuangYunnan Key Laboratory of Stomatology & Department of Cariology, Operative Dentistry and Endodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, China.
Xinhui MengYunnan Key Laboratory of Stomatology & Department of Cariology, Operative Dentistry and Endodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, China.
Yiquan WangYunnan Key Laboratory of Stomatology & Department of Cariology, Operative Dentistry and Endodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, China.
Jia LiangYunnan Key Laboratory of Stomatology & Department of Cariology, Operative Dentistry and Endodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, China.
Fengjiao ZhuYunnan Key Laboratory of Stomatology & Department of Cariology, Operative Dentistry and Endodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, China.
Rui SheYunnan Key Laboratory of Stomatology & Department of Cariology, Operative Dentistry and Endodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, China.
Shanshan HuangYunnan Key Laboratory of Stomatology & Department of Cariology, Operative Dentistry and Endodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, China.
Lijun HuoYunnan Key Laboratory of Stomatology & Department of Cariology, Operative Dentistry and Endodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: While the microbiome of caries-derived periapical lesions has been extensively characterized, the microbial profile of trauma-derived periapical lesions remains poorly understood. This study aimed to characterize the apical microbiome of trauma-derived periapical lesions and identify taxonomic differences between trauma- and caries-derived periapical lesions. Methods: Twenty patients with periapical lesions were enrolled, comprising 10 trauma-derived cases (trauma group) and 10 caries-derived cases (caries group). Microbial samples were collected using sterile paper points inserted into the root canal exudate, followed by DNA extraction and Illumina sequencing of the hypervariable V3-V4 regions of the 16S rRNA gene. Bioinformatic analyses included Results: Sequencing revealed 36 bacterial phyla and 587 genera across all samples. Trauma group showed significantly greater relative abundance of Conclusions: Trauma-derived periapical lesions exhibited reduced microbial diversity compared to caries-derived periapical lesions, with

Indexed as

campylobactermicrobiomenext-generation sequencingperiapical lesionsTrauma teeth

Identifiers

PMID41000236
PMCPMC12459192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.