ArticleFrontiers in pediatrics2025
Retrospective analysis of the analgosedative efficacy and safety of midazolam combined with fentanyl in mechanically ventilated neonates.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To compare the analgosedative efficacy and safety of the combination of midazolam and fentanyl with those of midazolam monotherapy in mechanically ventilated neonates. Materials and methods: We conducted a single-center retrospective analysis of mechanically ventilated patients in our neonatal intensive care unit from April 1, 2021 to December 1, 2024. After dividing patients into midazolam + fentanyl (M + F) and midazolam (M) groups according to their respective sedation/analgesia regimens, we conducted intergroup comparisons of pain scores, ventilator parameters, and vital signs 5 min pre-treatment and at post-treatment time points (1 h, 3 h, 12 h, 24 h, 48 h). We also compared pre-and post-treatment (3 h, 24 h, 48 h) non-invasive hemodynamic parameters; adverse reactions; and discharge outcomes of the two groups. Results: A total of 210 neonates were included, with 106 in the M + F group and 104 in the M group. N-PASS pain scores obtained 5 min pre-treatment were similar between the two groups ( Conclusion: The combination of midazolam and fentanyl relieved pain and reduced ventilator parameters more effectively than midazolam monotherapy, without increasing adverse reactions or worsening discharge outcomes among mechanically ventilated neonates.
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