ArticleNature synthesis2025
Geometric distortion as an enabling tool for organic synthesis.
Article in Nature synthesis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Diradical Character of Cyclic Allenes Enables Their Thermal (2 + 2) Cycloadditions.Journal of the American Chemical Society · 2026Article
- Complete Computational Exploration of Eight-Carbon Hydrocarbon Chemical Space.The Journal of organic chemistry · 2026Article
- Hyperpyramidalized alkenes with bond orders near 1.5 as synthetic building blocks.Nature chemistry · 2026Article
- Seven-Membered Azacyclic Allenes: Synthesis, Trapping, and Stereochemical Transfer Studies.Journal of the American Chemical Society · 2026Article
- Towards the selectivity and energetics of anti-Bredt olefins - a density functional theory approach.RSC advances · 2025Article
- Article
- Mechanisms of Kobayashi eliminations for the generation of highly strained arynes, cyclic cumulenes, and anti-Bredt olefins.Chemical science · 2025Article
- Development of a Vinylated Cyclic Allene: A Fleeting Strained Diene for the Diels-Alder Reaction.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
π-bonds are typically associated with well-defined arrangements of atoms. However, when the arrangement of atoms associated with these bonds becomes geometrically distorted, heightened reactivity is seen, enabling a wide range of transformations that can proceed under mild reaction conditions. As a result, molecules bearing complex structures can be rapidly assembled from simple building blocks. Here we describe the strategic use of synthetic building blocks containing π-bonds that feature geometric distortion, with a focus on recent applications to organic synthesis. The specific building blocks discussed are arynes, cyclic allenes, cyclic 1,2,3-trienes and anti-Bredt olefins. Developments in transition metal-mediated chemistry that enable previously unknown transformations are discussed, as well as new strategies for complex molecule and natural product synthesis that take advantage of geometrically distorted intermediates. We hope this Review will inspire future advances in the strategic use of geometric distortion in chemical synthesis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.