Evidence map›Paper›PMID 40999940›Full record

ArticleAging cell2025

Enhancing Late-Life Survival and Mobility via Mitohormesis by Reducing Mitochondrial Calcium Levels.

Doruntina Bresilla, Ines Tawfik, Martin Hirtl, Sonja Gabrijelčič, Julian Ostaku, Fabienne Mossegger, Lia Wurzer, Susanne Lederer, Katarina Kalinova, Ernst Malle and 4 more

Abstract read
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Doruntina BresillaDivision of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Ines TawfikDivision of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Martin HirtlDivision of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.ORCID 0000-0002-4322-5758
Sonja GabrijelčičDivision of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.ORCID 0009-0002-2024-1605
Julian OstakuDivision of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.ORCID 0000-0002-3648-1112
Fabienne MosseggerDivision of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Lia WurzerDivision of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Susanne LedererDivision of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Katarina KalinovaDivision of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.ORCID 0000-0002-4773-0823
Ernst MalleDivision of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
Markus SchossererCenter for Pathobiochemistry and Genetics, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-2025-0739
Kim ZarseCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Institute for Experimental Endocrinology, Berlin, Germany.
Michael RistowCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität Zu Berlin, Institute for Experimental Endocrinology, Berlin, Germany.
Corina T Madreiter-SokolowskiDivision of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.ORCID 0000-0002-8631-9949

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Austrian Science Fund 10.55776/FG24Austrian Science Fund 10.55776/P36235Austrian Science Fund 10.55776/P36591Hevolution/AFAR (American Foundation for Aging Research)NIH HHS P40 OD010440ORIP NIH HHS
6 · The paper itself

Abstract

Mitochondrial calcium (Ca

Indexed as

Caenorhabditis elegansCalciumHormesisLongevityMitochondriaAnimalsCaenorhabditis elegans ProteinsCalcium ChannelsHumansReactive Oxygen SpeciesCaenorhabditis elegans ProteinsCalciumCalcium Channelsmitochondrial calcium uniporterReactive Oxygen SpeciesagingC. eleganslifespanlongevitymitochondriareactive oxygen species

Identifiers

PMID40999940
PMCPMC12608091

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.